Trazpiroben

Modify Date: 2024-01-14 22:29:14

Use of Trazpiroben

Trazpiroben (TAK-906) is a dopamine D2/D3 receptor antagonist used for chronic research of moderate-to-severe gastroparesis[1].

Name	3-{[1-Cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-triazaspiro[4.5]dec-3-yl]methyl}benzoic acid
Synonym	More Synonyms

Description	Trazpiroben (TAK-906) is a dopamine D2/D3 receptor antagonist used for chronic research of moderate-to-severe gastroparesis[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
References	[1]. Kuo B, Scimia C, Dukes G, Zhang W, Gupta S, Chen C, Chuang E, Camilleri M. Randomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK-906), a dopamine D2 /D3 receptor antagonist, in patients with gastroparesis. Aliment Pharmacol Ther. 2021 Aug;54(3):267-280.

Density	1.3±0.1 g/cm3
Boiling Point	733.0±60.0 °C at 760 mmHg
Molecular Formula	C₃₁H₃₉N₃O₄
Molecular Weight	517.66
Flash Point	397.1±32.9 °C
Exact Mass	517.294067
LogP	5.19
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.636
InChIKey	BDXJYAAYLZTLEK-UHFFFAOYSA-N
SMILES	O=C(O)c1cccc(CN2CN(C3CCCCC3)C3(CCN(CCCC(=O)c4ccccc4)CC3)C2=O)c1

3-{[1-Cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-triazaspiro[4.5]dec-3-yl]methyl}benzoic acid

Benzoic acid, 3-[[1-cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-triazaspiro[4.5]dec-3-yl]methyl]-

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