Bromoacetamido-PEG2-C2-NHS ester

Modify Date: 2024-01-16 16:41:33

Bromoacetamido-PEG2-C2-NHS ester Structure
Bromoacetamido-PEG2-C2-NHS ester structure
Common Name Bromoacetamido-PEG2-C2-NHS ester
CAS Number 1353011-78-5 Molecular Weight 395.203
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C13H19BrN2O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bromoacetamido-PEG2-C2-NHS ester


Bromoacetamido-PEG2-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bromoacetamido-PEG2- NHS ester
Synonym More Synonyms

 Bromoacetamido-PEG2-C2-NHS ester Biological Activity

Description Bromoacetamido-PEG2-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C13H19BrN2O7
Molecular Weight 395.203
Exact Mass 394.037567
LogP -2.11
Index of Refraction 1.540

 Synonyms

Acetamide, 2-bromo-N-[2-[2-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]ethoxy]ethyl]-
2-Bromo-N-[2-(2-{3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy}ethoxy)ethyl]acetamide
MFCD20926375