AZD4320
Modify Date: 2024-01-06 22:31:54
AZD4320 structure
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Common Name | AZD4320 | ||
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| CAS Number | 1357576-48-7 | Molecular Weight | 945.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C45H48ClF3N4O7S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZD4320AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively. |
| Name | AZD4320 |
|---|
| Description | AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively. |
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| Related Catalog | |
| Target |
BCL2:17 nM (IC50, KPUM-UH1 cells) BCLxL:17 nM (IC50, KPUM-UH1 cells) |
| In Vitro | AZD4320 potently augments the antitumor effect of AZD5153 (Cat. No.: HY-100653A) in double expressing lymphoma (DEL)- and double hit lymphoma (DHL)-derived cell lines in a dose-dependent manner. AZD4320 shows mostly synergistic, and at least additive, growth inhibitory effects on DEL- and DHL derived cell lines, and profoundly increases cells undergoing apoptosis in all three cell lines[1]. |
| Cell Assay | Two DEL-derived cell lines, KPUM-MS3 and KPUM-UH1, and a DHL-derived cell line, STR-428 are used. To examine the combinatory growth inhibitory effects of AZD4320, cells are treated with five concentrations (0.25, 0.5, 1.0, 2.0, 4.0×IC50) for 72 h, and subjected to a modified MTT assay[1]. |
| References |
| Molecular Formula | C45H48ClF3N4O7S3 |
|---|---|
| Molecular Weight | 945.53 |
| Storage condition | 2-8°C |