Tetracaine hydrochloride
Tetracaine hydrochloride structure
|
Common Name | Tetracaine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 136-47-0 | Molecular Weight | 300.824 | |
| Density | N/A | Boiling Point | 389.4ºC at 760 mmHg | |
| Molecular Formula | C15H25ClN2O2 | Melting Point | 149°C | |
| MSDS | Chinese USA | Flash Point | 189.3ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Tetracaine hydrochlorideTetracaine HCl is a potent local anaesthetic and a channel function allosteric inhibitor.Target: Calcium ChannelTetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely [1, 2]. |
Summary: Tetracaine hydrochloride, Chinese name is 盐酸丁卡因, with CAS number 136-47-0, molecular formula C15H25ClN2O2, and molecular weight 300.824. It is a white or gray-white crystalline powder with a melting point of 149°C and is primarily used as a local anesthetic. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Tetracaine hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Tetracaine HCl is a potent local anaesthetic and a channel function allosteric inhibitor.Target: Calcium ChannelTetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely [1, 2]. |
|---|---|
| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 389.4ºC at 760 mmHg |
|---|---|
| Melting Point | 149°C |
| Molecular Formula | C15H25ClN2O2 |
| Molecular Weight | 300.824 |
| Flash Point | 189.3ºC |
| Exact Mass | 300.160461 |
| PSA | 41.57000 |
| LogP | 3.49200 |
| Vapour Pressure | 2.87E-06mmHg at 25°C |
| InChIKey | PPWHTZKZQNXVAE-UHFFFAOYSA-N |
| SMILES | CCCCNc1ccc(C(=O)OCCN(C)C)cc1.Cl |
| Storage condition | Refrigerator |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H317-H319 |
| Precautionary Statements | P280-P301 + P310-P305 + P351 + P338 |
| Hazard Codes | T:Toxic |
| Risk Phrases | R25;R36;R43 |
| Safety Phrases | S26-S36/37-S45-S36/37/39-S22-S53 |
| RIDADR | 2811 |
| RTECS | DG4900000 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 2942000000 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
|---|---|
| DownStream 2 | |
CAS#:108-01-0
CAS#:4740-24-3This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2942000000 |
|---|
This table lists relevant public references with title, journal and publication metadata for this compound.
|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ... |
|
|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ... |
|
|
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Ameth |
| Tetracaine (hydrochloride) |
| Tetracaine HCl |
| MFCD00038912 |
| curtacain |
| EINECS 205-248-5 |
| PANTOCAINE |
| gingicainm |
| decicaine |
| anethaine |
| 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Amethocaine hydrochloride |
| anacel |
| butethanol |
| tonexol |
| decicain |
| menonasal |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of Tetracaine hydrochloride? |
| A: SMILES notation of Tetracaine hydrochloride is CCCCNc1ccc(C(=O)OCCN(C)C)cc1.Cl. |
| Q: What is the safety information for Tetracaine hydrochloride? |
| A: Safety information for Tetracaine hydrochloride: S26-S36/37-S45-S36/37/39-S22-S53. |
| Q: What is the boiling point of Tetracaine hydrochloride? |
| A: Boiling point of Tetracaine hydrochloride is 389.4ºC at 760 mmHg. |
| Q: What English synonyms does Tetracaine hydrochloride have? |
| A: English synonyms of Tetracaine hydrochloride: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Ameth, Tetracaine (hydrochloride), Tetracaine HCl, MFCD00038912, curtacain, EINECS 205-248-5, PANTOCAINE, gingicainm, decicaine, anethaine, 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Amethocaine hydrochloride, anacel, butethanol, tonexol, decicain, menonasal. |
| Q: What is the molecular weight of Tetracaine hydrochloride? |
| A: Molecular weight of Tetracaine hydrochloride is 300.824. |
| Q: What is the melting point of Tetracaine hydrochloride? |
| A: Melting point of Tetracaine hydrochloride is 149°C. |
| Q: What is the LogP of Tetracaine hydrochloride? |
| A: LogP of Tetracaine hydrochloride is 3.49200. |
| Q: What are the downstream products of Tetracaine hydrochloride? |
| A: Related downstream products(CAS) of Tetracaine hydrochloride: 108-01-0;4740-24-3. |
| Q: What are the storage conditions for Tetracaine hydrochloride? |
| A: Storage conditions for Tetracaine hydrochloride: Refrigerator. |
| Q: What is the InChIKey of Tetracaine hydrochloride? |
| A: InChIKey of Tetracaine hydrochloride is PPWHTZKZQNXVAE-UHFFFAOYSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |