ML368
Modify Date: 2024-05-12 14:01:24
ML368 structure
|
Common Name | ML368 | ||
|---|---|---|---|---|
| CAS Number | 1361414-26-7 | Molecular Weight | 430.46100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H18N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML368SR9186 (ML368) is a potent CYP3A4 inhibitor with IC50 s for inhibition of midazolam → 1′hydroxymidazolam, testosterone → 6β-hydroxytestosterone, and vincristine → vincristine M1 of 9, 4, and 38 nM, respectively. SR-9186 inhibits liver-stage development of P. falciparum to block ivermectin metabolism[1]. |
| Name | 1-(4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl)-3-(4'-cyano-[1,1'-biphenyl]-4-yl)urea |
|---|---|
| Synonym | More Synonyms |
| Description | SR9186 (ML368) is a potent CYP3A4 inhibitor with IC50 s for inhibition of midazolam → 1′hydroxymidazolam, testosterone → 6β-hydroxytestosterone, and vincristine → vincristine M1 of 9, 4, and 38 nM, respectively. SR-9186 inhibits liver-stage development of P. falciparum to block ivermectin metabolism[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C26H18N6O |
|---|---|
| Molecular Weight | 430.46100 |
| Exact Mass | 430.15400 |
| PSA | 106.49000 |
| LogP | 5.95358 |
| SR-9186 |
| N-(4'-Cyano[1,1'-biphenyl]-4-yl)-N'-[4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl] Urea |