Senexin A
Modify Date: 2024-01-01 17:16:24
Senexin A structure
|
Common Name | Senexin A | ||
|---|---|---|---|---|
| CAS Number | 1366002-50-7 | Molecular Weight | 274.32000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H14N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Senexin ASenexin A is a CDK8 inhibitor with an IC50 of 280 nM. |
| Name | 4-(Phenethylamino)quinazoline-6-carbonitrile |
|---|---|
| Synonym | More Synonyms |
| Description | Senexin A is a CDK8 inhibitor with an IC50 of 280 nM. |
|---|---|
| Related Catalog | |
| Target |
CDK19:0.31 μM (Kd) CDK8:0.83 μM (Kd) |
| In Vitro | Senexin A inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 μM and 0.31 μM, respectively and CDK8 kinase activity with IC50 of 0.28 μM. Senexin A inhibits β-catenin–dependent transcription in HCT116 colon carcinoma cells. The induction of transcription factor EGR1 upon serum starvation, followed by readdition of serum, is strongly inhibited by Senexin A in HT1080 cells. Senexin A inhibits only p21-induced transcription but not other biological effects of p21. Senexin A also decreases the expression of many secreted tumor-promoting factors in doxorubicin-treated wild-type HCT116 cells[1]. |
| In Vivo | Five daily treatment of Senexin A fully reverses tumor-promoting effect of chemotherapy. Senexin A shows no detectable toxicity and no significant effects on body weight, organ weights, or blood cell counts in C57BL/6 mice during the treatment. This effect of doxorubicin treatment is completely abolished, however, when doxorubicin injection is followed by administration of Senexin A. Senexin A treatment strongly improves the response of A549/MEF tumors to doxorubicin[1]. |
| Animal Admin | Mice: Senexin A toxicity study is conducted by Taconic in C57BL/6 mice, using five mice per group treated with 20 mg/kg Senexin A or carrier (80% propylene glycol), with five daily i.p. injections. Mice are weighed on days 3 and 6, and killed on day 6. Organ weights are determined for brain, kidney, thymus, spleen, lung, and liver. Terminal blood samples are analyzed to determine the numbers of total white blood cells, neutrophils, lymphocytes, monocytes, eosinophils, and basophils[1]. |
| References |
| Molecular Formula | C17H14N4 |
|---|---|
| Molecular Weight | 274.32000 |
| Exact Mass | 274.12200 |
| PSA | 61.60000 |
| LogP | 3.22908 |
| Storage condition | -20℃ |
| Senexin A |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 4-(Phenethylamino)quinazoline-6-carbonitrile
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Senexin A
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: Senexin A
- Price: $650.0/100mg $1300.0/250mg $2600.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Senexin A
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: $151/10mM*1mLinDMSO
Reference only. check more Senexin A price