Mant-GTPγS

Modify Date: 2025-09-11 11:16:24

Use of Mant-GTPγS

Mant-GTPγS, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS is a potent YdeH inhibitor[1][2][3].

Name	Mant-GTPγS

Description	Mant-GTPγS, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS is a potent YdeH inhibitor[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase
References	[1]. Andreas Gille, et al. 2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors. J Biol Chem. 2003 Apr 11;278(15):12672-9. [2]. Tomoharu Kanie, et al. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017 Jul 10;42(1):22-36.e12. [3]. Christian Spangler, et al. Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2',(3')-substituted purine and pyrimidine nucleotides. J Pharmacol Exp Ther. 2011 Jan;336(1):234-41.

Description

Mant-GTPγS, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS is a potent YdeH inhibitor[1][2][3].

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase

References

Molecular Formula	C₁₈H₂₃N₆O₁₄P₃S
Molecular Weight	672.39
InChIKey	JOKHYBKUVDNQEA-XNIJJKJLSA-N
SMILES	CNc1ccccc1C(=O)OC1C(O)C(COP(=O)(O)OP(=O)(O)OP(O)(O)=S)OC1n1cnc2c(=O)[nH]c(N)nc21

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