cAMP is produced by adenylatecyclase (AC), a 12-transmembrane-spanning enzyme that catalyzes the conversion of ATP to 3′,5′-cAMP and pyrophosphate. In neuronal and neuroendocrine cells, a variety of ligands, such as neurotransmitters and hormones, signal via activation of G protein coupled receptors (GPCRs) coupled to GSα. These receptors activate adenylatecyclases (ACs), the family of enzymes that generate cAMP. cAMP is synthesized by adenylatecyclases (ACs) and degraded by phosphodiesterases (PDEs). Local cAMP signaling is achieved by targeting of signaling components to subcellular compartments and assembly of signaling complexes. Primary cilia also host several cAMP-signaling components: the somatostatin 3 receptor (SSTR3), various adenylatecyclases (AC3, AC4, AC6, AC8), PKA, and Epac2 (exchange protein directly activated by cAMP).


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15-PGDH 5 alpha Reductase 5-Lipoxygenase Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldehyde Dehydrogenase (ALDH) Aldose Reductase Aminopeptidase Angiotensin-converting Enzyme (ACE) ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dipeptidyl Peptidase Dopamine β-hydroxylase E1/E2/E3 Enzyme Elastase Enolase FAAH FABP Factor Xa Farnesyl Transferase Fatty Acid Synthase (FAS) FXR Glucokinase GSNOR Gutathione S-transferase HCV Protease Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Isocitrate Dehydrogenase (IDH) Lactate Dehydrogenase LXR MAGL Mineralocorticoid Receptor Mitochondrial Metabolism MMP Nampt NEDD8-activating Enzyme Neprilysin PAI-1 PDHK PGC-1α Phosphatase Phosphodiesterase (PDE) Phospholipase Procollagen C Proteinase Proteasome Pyruvate Kinase RAR/RXR Renin ROR Ser/Thr Protease SGK Stearoyl-CoA Desaturase (SCD) Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase
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5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
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Adenylyl cyclase-IN-1

Adenylyl cyclase-IN-1 is an adenylyl cyclase inhibitor with potential use in ocular hypotonia research[1].

  • CAS Number: 731827-16-0
  • MF: C9H8N2S3
  • MW: 240.37
  • Catalog: Adenylate Cyclase
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 352.5±35.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 167.0±25.9 °C

PACAP (6-27) (human, ovine, rat)

PACAP (6-27) (human, ovine, rat) is a PACAP receptor antagonist that blocks the canine adrenal catecholamine response to exogenous vasoactive intestinal peptide (VIP). PACAP (6-27) (human, ovine, rat) has the potential to study cardiovascular and neurological diseases[1].

  • CAS Number: 136134-68-4
  • MF: C121H193N33O31S
  • MW: 2638.09
  • Catalog: Adenylate Cyclase
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 1561.8±75.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 898.4±37.1 °C

Adenylyl cyclase type 2 agonist-1

Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC50 of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases[1].

  • CAS Number: 2414908-52-2
  • MF: C27H17BrClNO5
  • MW: 550.78
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

TIP-39 trifluoroacetate salt

TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R)[1].

  • CAS Number: 277302-47-3
  • MF: C202H325N61O54S
  • MW:
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Cholera toxin

Cholera toxin is a multifunctional protein produced by Vibrio cholera. Cholera toxin is not just another enterotoxin that causes cholera but also able to influence the immune system in many ways.

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Small Cardioactive Peptide B (SCPB)

Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.

  • CAS Number: 84746-43-0
  • MF: C52H80N14O11S2
  • MW: 1141.41000
  • Catalog: Peptides
  • Density: 1.41 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Forskolin

Forskolin is a potent adenylate cyclase activator, with IC50 and EC50 of 41 nM and 0.5 μM for type I adenylyl cyclase, respectively.

  • CAS Number: 66575-29-9
  • MF: C22H34O7
  • MW: 410.501
  • Catalog: Autophagy
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 519.9±50.0 °C at 760 mmHg
  • Melting Point: 282-232ºC
  • Flash Point: 171.8±23.6 °C

NKH477

NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].

  • CAS Number: 138605-00-2
  • MF: C27H44ClNO8
  • MW: 546.093
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: 571.4ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 176ºC

NB 001

NB001 (HTS 09836) is an adenylcyclase 1 (AC1) inhibitor which has effect on neural and non-neural pain by modulating AC1 activity[1].

  • CAS Number: 686301-48-4
  • MF: C12H20N6O
  • MW: 264.32700
  • Catalog: Adenylate Cyclase
  • Density: 1.37 g/cm3
  • Boiling Point: 521.3ºC at 760 mmHg
  • Melting Point: 146-148ºC
  • Flash Point: 269.1ºC

Vasopressin, 8-l-lysine-, monoacetate (salt)

Lysipressin (acetate) is Antidiuretic hormone that have been found in pigs and some marsupial families. Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase[1][2].

  • CAS Number: 83968-49-4
  • MF: C48H69N13O14S2
  • MW: 1116.270
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

CB-7921220

CB-7921220 is an adenylate cyclase inhibitor.

  • CAS Number: 115453-99-1
  • MF: C14H12N2O2
  • MW: 240.261
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 225 - 226 °C
  • Flash Point: N/A

α-MSH trifluoroacetate salt

α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.

  • CAS Number: 581-05-5
  • MF: C77H109N21O19S
  • MW: 1664.884
  • Catalog: Peptides
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

SKF-83566

SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM)[1][3]. SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM[2]. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta[4]. SKF-83566 can be used for research of parkinson’s disease and nicotine craving alleviation[5].

  • CAS Number: 99295-33-7
  • MF: C17H19BrClNO
  • MW: 368.69600
  • Catalog: 5-HT Receptor
  • Density: N/A
  • Boiling Point: 447.5ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 224.4ºC

LRE1

LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.

  • CAS Number: 1252362-53-0
  • MF: C12H13ClN4S
  • MW: 280.78
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

9-CP-Ade mesylate

9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive adenylate cyclase inhibitor with cell permeable properties[1][2].

  • CAS Number: 189639-09-6
  • MF: C11H17N5O3S
  • MW: 299.34900
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: 440.5ºC at 760 mmHg
  • Melting Point: 180-183ºC(lit.)
  • Flash Point: 220.2ºC

Mant-GTPγS

Mant-GTPγS, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS is a potent YdeH inhibitor[1][2][3].

  • CAS Number: 136749-24-1
  • MF: C18H23N6O14P3S
  • MW: 672.39
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Attentil

Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is a nootropic drug. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research[1].

  • CAS Number: 34161-23-4
  • MF: C20H22Cl2N2O4
  • MW: 425.30600
  • Catalog: Adenylate Cyclase
  • Density: 1.342g/cm3
  • Boiling Point: 559.3ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 292.1ºC

2',5'-Dideoxyadenosine

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].

  • CAS Number: 6698-26-6
  • MF: C10H13N5O2
  • MW: 235.24300
  • Catalog: Adenylate Cyclase
  • Density: 1.77 g/cm3
  • Boiling Point: 547ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 284.6ºC

NKY 80

NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues[1][2].

  • CAS Number: 299442-43-6
  • MF: C12H11N3O2
  • MW: 229.23500
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ST 034307

ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.

  • CAS Number: 133406-29-8
  • MF: C10H4Cl4O2
  • MW: 297.95000
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

dynorphin (1-11), Pro(10)-

[DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property[1][2].

  • CAS Number: 94596-26-6
  • MF: C63H103N21O13
  • MW: 1362.62000
  • Catalog: Adenylate Cyclase
  • Density: 1.42±0.1 g/cm3 (20 °C, 760 mmHg)
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MDL 12330A hydrochloride

MDL12330A (RMI12330A) is an adenyl cyclase inhibitor. MDL12330A inhibits the vasopressin action on the short-circuit current (SCC). MDL12330A is also an inhibitor of cAMP phosphodiesterase[1].

  • CAS Number: 40297-09-4
  • MF: C23H37ClN2
  • MW: 377.01
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: 515ºC at 760 mmHg
  • Melting Point: 148 - 152 °C
  • Flash Point: 265.2ºC

Angiopeptin TFA

Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibit adenylate cyclase or stimulate extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research[1][2].

  • CAS Number: 2478421-60-0
  • MF: C58H73F6N11O14S2
  • MW: 1326.39
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Albanin A

Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca2+/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity[1].

  • CAS Number: 73343-42-7
  • MF: C20H18O6
  • MW: 354.35300
  • Catalog: Adenylate Cyclase
  • Density: 1.408g/cm3
  • Boiling Point: 621.7ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 225.4ºC

Tyr-α-CGRP (23-37) (mouse, rat)

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and adenylate cyclase. Calcitonin is mainly produced by thyroid C cells while CGRP is secreted and stored in the nervous system[1].

  • CAS Number: 198277-54-2
  • MF: C82H120N20O25
  • MW: 1785.95000
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BMY 45778

BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor[1].

  • CAS Number: 152575-66-1
  • MF: C26H18N2O5
  • MW: 438.43
  • Catalog: Adenylate Cyclase
  • Density: 1.298g/cm3
  • Boiling Point: 659.9ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 352.9ºC

SQ22536

SQ22536 is an effective adenylate cyclase (AC) inhibitor.

  • CAS Number: 17318-31-9
  • MF: C9H11N5O
  • MW: 205.217
  • Catalog: Adenylate Cyclase
  • Density: 1.7±0.1 g/cm3
  • Boiling Point: 474.8±55.0 °C at 760 mmHg
  • Melting Point: 160-161ºC
  • Flash Point: 241.0±31.5 °C

Zelminemab

Zelminemab (AMG-301) is a human monoclonal antibody that inhibits PACAP type I (PAC1) receptor[1].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies[1][2][3].

  • CAS Number: 148892-91-5
  • MF: C10H14N6Na3O13P3
  • MW: 588.141
  • Catalog: Adenylate Cyclase
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 230 °C
  • Flash Point: N/A