PBTZ169
Modify Date: 2024-01-13 16:21:40
PBTZ169 structure
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Common Name | PBTZ169 | ||
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| CAS Number | 1377239-83-2 | Molecular Weight | 456.482 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 555.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C20H23F3N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 289.8±32.9 °C | |
Use of PBTZ169Macozinone is a new drug candicate that inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043target: DprE1In vitro: PBTZ169, inhibit decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1) and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. [1]In vivo: PBTZ169 can be suspend in 0.25% hydroxy-propylmethyl-cellulose. The administertration for PBTZ169 is 100 mg/kg by gavage. The MIC50 and MIC90 values were 0.0075 and 0.030 μg/mL, respectively. The MIC for PBTZ169 for N. brasiliensis HUJEG-1 was 0.0037 μg/mL.[2] PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB). [3] |
| Name | 2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one |
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| Synonym | More Synonyms |
| Description | Macozinone is a new drug candicate that inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043target: DprE1In vitro: PBTZ169, inhibit decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1) and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. [1]In vivo: PBTZ169 can be suspend in 0.25% hydroxy-propylmethyl-cellulose. The administertration for PBTZ169 is 100 mg/kg by gavage. The MIC50 and MIC90 values were 0.0075 and 0.030 μg/mL, respectively. The MIC for PBTZ169 for N. brasiliensis HUJEG-1 was 0.0037 μg/mL.[2] PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB). [3] |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 555.6±60.0 °C at 760 mmHg |
| Molecular Formula | C20H23F3N4O3S |
| Molecular Weight | 456.482 |
| Flash Point | 289.8±32.9 °C |
| Exact Mass | 456.144287 |
| LogP | 3.83 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.660 |
| 2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one |
| 4H-1,3-Benzothiazin-4-one, 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)- |
| PBTZ169 |