PBTZ169

• 常用名: PBTZ169
• 英文名: PBTZ169
• CAS号: 1377239-83-2
• 分子量: 456.482
• 密度: 1.5±0.1 g/cm3
• 沸点: 555.6±60.0 °C at 760 mmHg
• 分子式: C₂₀H₂₃F₃N₄O₃S
• 熔点: N/A
• 闪点: 289.8±32.9 °C

PBTZ169用途

Macozinone 是一个能抑制DprE1的药物候选者,比BTZ043更有效

PBTZ169名称

• 中文名: Macozinone
• 英文名: 2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

PBTZ169生物活性

• 描述: Macozinone 是一个能抑制DprE1的药物候选者,比BTZ043更有效
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. [1] Makarov V et al. The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52.

  [2]. [2] González-Martínez NA et al. In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022.

  [3]. [3] Makarov V et al. Towards a new combination therapy for tuberculosis with next generation benzothiazinones.EMBO Mol Med. 2014 Mar;6(3):372-83.

PBTZ169物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 555.6±60.0 °C at 760 mmHg
• 分子式: C₂₀H₂₃F₃N₄O₃S
• 分子量: 456.482
• 闪点: 289.8±32.9 °C
• 精确质量: 456.144287
• LogP: 3.83
• InChIKey: BJDZBXGJNBMCAV-UHFFFAOYSA-N
• SMILES: O=c1nc(N2CCN(CC3CCCCC3)CC2)sc2c([N+](=O)[O-])cc(C(F)(F)F)cc12
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.660
• 储存条件: -20°C，密闭，干燥

PBTZ169靶点实验

查看更多实验

实验名称：Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as bacteria... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5265568

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：AUC (0 to infinity) in ICR mouse at 50 mg/kg, po administered as single dose by HPLC ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4231671

实验名称：Oral bioavailability in Sprague-Dawley rat at 200 mg/kg measured upto 24 hrs by HPLC ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4362494

实验名称：Oral bioavailability in Sprague-Dawley rat at 50 mg/kg measured upto 24 hrs by HPLC a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4362493

实验名称：Oral bioavailability in Sprague-Dawley rat at 25 mg/kg measured upto 24 hrs by HPLC a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4362492

实验名称：MRT in ICR mouse at 50 mg/kg, po administered as single dose by HPLC analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4231672

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 200 mg/kg, po by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4362491

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PBTZ169英文别名

• 2-[4-(Cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
• PBTZ169