picrocrocin

Modify Date: 2024-01-04 17:10:08

picrocrocin Structure
picrocrocin structure
Common Name picrocrocin
CAS Number 138-55-6 Molecular Weight 330.37300
Density 1.31g/cm3 Boiling Point 520.4ºC at 760mmHg
Molecular Formula C16H26O7 Melting Point 196 ºC (ethyl acetate )
MSDS N/A Flash Point 187.1ºC

 Use of picrocrocin


Picrocrocin, an apocarotenoid found in the flowers of Cochliobolus sativus. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells[1].

 Names

Name picrocrocin
Synonym More Synonyms

 picrocrocin Biological Activity

Description Picrocrocin, an apocarotenoid found in the flowers of Cochliobolus sativus. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells[1].
Related Catalog
In Vitro Picrocrocin exerted growth inhibitory effects on the SK-MEL-2 melanoma cells. The IC50 of picrocrocin against the SK-MEL-2 cells was 20 μM at 24-h incubation. The antiproliferative activity of picrocrocin was due to apoptosis and cell cycle arrest. In addition, picrocrocin enhanced the ROS levels and decreased the MMP levels of SK-MEL-2 cells. Finally, picrocrocin inhibited the JAK/STAT5 signalling pathway in the SK-MEL-2 melanoma cells[1].
References

[1]. Yu L, et al. Picrocrocin exhibits growth inhibitory effects against SKMEL- 2 human malignant melanoma cells by targeting JAK/ STAT5 signaling pathway, cell cycle arrest and mitochondrial mediated apoptosis. J BUON. 2018 Jul-Aug;23(4):1163-1168.

 Chemical & Physical Properties

Density 1.31g/cm3
Boiling Point 520.4ºC at 760mmHg
Melting Point 196 ºC (ethyl acetate )
Molecular Formula C16H26O7
Molecular Weight 330.37300
Flash Point 187.1ºC
Exact Mass 330.16800
PSA 116.45000
Vapour Pressure 5.27E-13mmHg at 25°C
Index of Refraction 1.561
Water Solubility Sparingly soluble (24 g/L) (25 ºC)

 Synthetic Route

~10%

picrocrocin Structure

picrocrocin

CAS#:138-55-6

Literature: Mayer; Santer Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1463 - 1466

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picrocrocin Structure

picrocrocin

CAS#:138-55-6

Literature: Mayer; Santer Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1463 - 1466

~%

picrocrocin Structure

picrocrocin

CAS#:138-55-6

Literature: Mayer; Santer Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1463 - 1466

~%

picrocrocin Structure

picrocrocin

CAS#:138-55-6

Literature: Mayer; Santer Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1463 - 1466

 Synonyms

saffron-bitter
Picrocrocine
(4R)-2,6,6-trimethyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycyclohexene-1-carbaldehyde
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