Necrox-5 methanesulfonate
Modify Date: 2024-01-09 16:54:28
Necrox-5 methanesulfonate structure
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Common Name | Necrox-5 methanesulfonate | ||
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| CAS Number | 1383718-29-3 | Molecular Weight | 645.808 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H39N3O9S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Necrox-5 methanesulfonateNecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity. |
| Name | NecroX-5 |
|---|---|
| Synonym | More Synonyms |
| Description | NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity. |
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| Related Catalog | |
| Target |
Calcium channel[1] |
| In Vitro | NecroX-5 (10 or 40 μM) inhibits breast cancer cell migration, which is correlated with mitoROS reduction, and mediated by AKT inhibition. NecroX-5 (10 μM) decreases intracellular calcium concentration in 4T1 cells by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT downregulation and the reduction of mitochondrial ROS levels[1]. NecroX-5 (10 µM) treatment for 24 h, effectively decreases the increased TNFα, TGFβ1, pSmad2 and the expression of Dcn in LPS-stimulated H9C2 cells[2]. |
| In Vivo | NecroX-5 (2.5 mg/kg, everyday other day) inhibits breast cancer cell metastasis in TUBO-P2J tumour-bearing mice[1]. |
| References |
| Molecular Formula | C27H39N3O9S3 |
|---|---|
| Molecular Weight | 645.808 |
| Exact Mass | 645.184814 |
| Storage condition | 2-8℃ |
| 1H-Indol-7-amine, 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-, methanesulfonate (1:2) |
| 5-[(1,1-Dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-(tetrahydro-2H-pyran-4-ylmethyl)-1H-indol-7-amine methanesulfonate (1:2) |