SYP-5

Modify Date: 2025-08-25 12:29:04

SYP-5 Structure
SYP-5 structure
Common Name SYP-5
CAS Number 1384268-04-5 Molecular Weight 312.383
Density 1.3±0.1 g/cm3 Boiling Point 502.0±50.0 °C at 760 mmHg
Molecular Formula C18H16O3S Melting Point N/A
MSDS N/A Flash Point 257.4±30.1 °C

 Use of SYP-5


SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.

 Names

Name SYP-5
Synonym More Synonyms

 SYP-5 Biological Activity

Description SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.
Related Catalog
Target

HIF[1]

In Vitro SYP-5 inhibits hypoxia-induced upregulation of HIF-1. SYP-5 inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down-regulated by SYP-5. SYP-5 displays significant inhibition on hypoxia-induced overexpression of VEGF and MMP2 in both cell lines. In the tube formation assay, SYP-5 suppresses angiogenesis induced by hypoxia and VEGF in vitro. SYP-5 also retards the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS. SYP-5 specifically inhibits hypoxic induction of luciferase expression in U251-HRE but not in U251-pGL3[1].
Cell Assay The cells (1×105 cells/mL) are seeded into 96-well culture plates. After overnight ncubation, the cells are treated with various concentrations of SYP-5 (2, 10, 50 μM) for 24 h. Then 10μLMTT) solution (2.5 mg/mL in PBS) is added to each well, and the plates are incubated for additional 4 h at 37°C. After centrifugation (2500 rpm, 10 min), the medium containing MTT is aspirated, and 100 μL DMSO is added. The optical density of each well is measured at 570 nm with a SpectraMax Paradigm Reader[1].
References

[1]. Wang LH, et al. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur J Pharmacol. 2016 Nov 15;791:560-568.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 502.0±50.0 °C at 760 mmHg
Molecular Formula C18H16O3S
Molecular Weight 312.383
Flash Point 257.4±30.1 °C
Exact Mass 312.082001
LogP 6.34
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.649
Storage condition 2-8℃

 Synonyms

(2E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(2-thienyl)-2-propen-1-one
2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-
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