marmesin

Modify Date: 2025-08-25 11:47:26

marmesin structure	Common Name	marmesin
	CAS Number	13849-08-6	Molecular Weight	246.259
	Density	1.3±0.1 g/cm3	Boiling Point	434.0±45.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₄O₄	Melting Point	189-191℃
	MSDS	N/A	Flash Point	168.0±22.2 °C

Use of marmesin

S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.

Name	(+)-marmesin
Synonym	More Synonyms

Description	S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Others Natural Products >> Phenylpropanoids
Target	COX-2 5-Lipoxygenase
In Vitro	S-(+)-Marmesin ((+)-marmesin) shows affinity at the recombinant psoralen synthase, with a Km of 1.5 ± 0.5 μM, exceeding the substrate affinities of other enzymes of the CYP71 subfamily involved in plant secondary metabolism[1]. S-(+)-Marmesin ((+)-marmesin) shows COX-2/5-LOX dual inhibitory activity[2].
References	[1]. Larbat R, et al. Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis. J Biol Chem. 2007 Jan 5;282(1):542-54. Epub 2006 Oct 26. [2]. Kim JS, et al. Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. Arch Pharm Res. 2006 Aug;29(8):617-23.

Density	1.3±0.1 g/cm3
Boiling Point	434.0±45.0 °C at 760 mmHg
Melting Point	189-191℃
Molecular Formula	C₁₄H₁₄O₄
Molecular Weight	246.259
Flash Point	168.0±22.2 °C
Exact Mass	246.089203
PSA	59.67000
LogP	1.69
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.611
InChIKey	FWYSBEAFFPBAQU-LBPRGKRZSA-N
SMILES	CC(C)(O)C1Cc2cc3ccc(=O)oc3cc2O1
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1045500

CHEMICAL NAME :: 7H-Furo(3,2-g)(1)benzopyran-7-one, 2,3-dihydro-2-(1-hydroxy-1-methylethyl)-, (S)-(+)-

CAS REGISTRY NUMBER :: 13849-08-6

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H14-O4

MOLECULAR WEIGHT :: 246.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1040 ng/plate

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 13,521,1984

Name: Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate at 500 uM after...
Source: ChEMBL
Target: Beta-secretase 1
External Id: CHEMBL1936882

Name: Screen for inhibitors of RMI FANCM (MM2) intereaction
Source: 11908
Target: N/A
External Id: RMI-FANCM-MM2

Name: Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins b...
Source: ChEMBL
Target: Beta-secretase 1
External Id: CHEMBL1936881

Name: Inhibition of aromatase from human placental microsomes
Source: ChEMBL
Target: Aromatase
External Id: CHEMBL949646

Name: Cytotoxicity against human SK-MEL-2 cells assessed as growth inhibition after 72 hrs ...
Source: ChEMBL
Target: SK-MEL-2
External Id: CHEMBL3122532

Name: Antifungal activity against Candida albicans B311 ATCC 90028 by antimicrobial suscept...
Source: ChEMBL
Target: Candida albicans
External Id: CHEMBL986649

Name: Cytotoxicity against human CAKI-1 cells assessed as growth inhibition after 72 hrs by...
Source: ChEMBL
Target: CAKI-1
External Id: CHEMBL3122534

Name: Spectrum HTS for Inhibitors of Aerobactin Synthetase IucA
Source: 23265
Target: IucA Synthetase from hypervirulent Klebsiella pneumoniae hvKP1
External Id: IucA Pilot Assay Spectrum Library

Name: Cytotoxicity against human 1A9 cells assessed as growth inhibition after 72 hrs by SR...
Source: ChEMBL
Target: 1A9
External Id: CHEMBL3122535

Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491

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2-(2-Hydroxy-2-propanyl)-2,3-dihydro-7H-furo[3,2-g]chromen-7-one

2,3-dihydro-2-(1-hydroxy-1-methylethyl)-7H-furo[3,2-g][1]benzopyran-7-one

(7S)-marmesin

marmesin

2-(2-hydroxypropan-2-yl)-2,3-dihydro-7H-furo[3,2-g]chromen-7-one

2-(1-Hydroxy-1-methyl-ethyl)-2,3-dihydro-furo[3,2-g]chromen-7-one

S(+)-Marmesin

2-(1-Hydroxy-1-methylethyl)-2,3-dihydrofuro[3,2-g]chromen-7-one

(2S)-2-(2-hydroxypropan-2-yl)-2,3-dihydrofuro[3,2-g]chromen-7-one

S-(+)-Marmesin

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China
Product Name: marmesin
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: marmesin
Price: ￥2748.0/10mg
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

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marmesin

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Chemical & Physical Properties

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

marmesinBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.