[Lys8, Lys9]-Neurotensin (8-13)

Modify Date: 2024-01-10 17:14:31

[Lys8, Lys9]-Neurotensin (8-13) structure	Common Name	[Lys8, Lys9]-Neurotensin (8-13)
	CAS Number	139026-64-5	Molecular Weight	760.96400
	Density	1.203 g/cm3	Boiling Point	1109.7ºC at 760 mmHg
	Molecular Formula	C₃₈H₆₄N₈O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	624.9ºC

Use of [Lys8, Lys9]-Neurotensin (8-13)

[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].

Name	[Lys8,9]-Neurotensin (8-13),KKPYIL
Synonym	More Synonyms

Description	[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease
References	[1]. Emilie Eiselt, et al. Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS Chem Neurosci. 2019 Nov 20;10(11):4535-4544.

Density	1.203 g/cm3
Boiling Point	1109.7ºC at 760 mmHg
Molecular Formula	C₃₈H₆₄N₈O₈
Molecular Weight	760.96400
Flash Point	624.9ºC
Exact Mass	760.48500
PSA	272.30000
LogP	4.22940
Storage condition	-20°C