(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)

Modify Date: 2025-08-25 15:58:43

(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13) structure	Common Name	(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)
	CAS Number	139026-66-7	Molecular Weight	746.980
	Density	1.2±0.1 g/cm3	Boiling Point	1044.2±65.0 °C at 760 mmHg
	Molecular Formula	C₃₈H₆₆N₈O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	585.3±34.3 °C

Use of (Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)

JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.5 nM in binding to mouse brain membranes and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].

Name	jmv 449
Synonym	More Synonyms

Description	JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.5 nM in binding to mouse brain membranes and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease
References	[1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198. [2]. Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor

Research Areas >> Neurological Disease

References

[1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198.

[2]. Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.

Density	1.2±0.1 g/cm3
Boiling Point	1044.2±65.0 °C at 760 mmHg
Molecular Formula	C₃₈H₆₆N₈O₇
Molecular Weight	746.980
Flash Point	585.3±34.3 °C
Exact Mass	746.505432
PSA	255.23000
LogP	2.02
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.556

L-Leucine, N-[(2S)-2,6-diaminohexyl]-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-

N-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine

m.w. 746.96 c38h66n8o7

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(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)

Use of (Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)

Names

(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13) Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.