(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)

Modify Date: 2024-01-22 19:50:56

(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13) Structure
(Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13) structure
Common Name (Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)
CAS Number 139026-66-7 Molecular Weight 746.980
Density 1.2±0.1 g/cm3 Boiling Point 1044.2±65.0 °C at 760 mmHg
Molecular Formula C38H66N8O7 Melting Point N/A
MSDS N/A Flash Point 585.3±34.3 °C

 Use of (Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)


JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.5 nM in binding to mouse brain membranes and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].

 Names

Name jmv 449
Synonym More Synonyms

 (Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13) Biological Activity

Description JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.5 nM in binding to mouse brain membranes and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].
Related Catalog
References

[1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198.

[2]. Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 1044.2±65.0 °C at 760 mmHg
Molecular Formula C38H66N8O7
Molecular Weight 746.980
Flash Point 585.3±34.3 °C
Exact Mass 746.505432
PSA 255.23000
LogP 2.02
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.556

 Synonyms

L-Leucine, N-[(2S)-2,6-diaminohexyl]-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-
N-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine
m.w. 746.96 c38h66n8o7
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