L-689,560
Modify Date: 2024-01-05 19:55:13
L-689,560 structure
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Common Name | L-689,560 | ||
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| CAS Number | 139051-78-8 | Molecular Weight | 380.22500 | |
| Density | 1.51g/cm3 | Boiling Point | 549.1ºC at 760 mmHg | |
| Molecular Formula | C17H15Cl2N3O3 | Melting Point | 172-173ºC | |
| MSDS | N/A | Flash Point | 285.9ºC | |
Use of L-689,560L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2]. |
| Name | L-689,560,trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline |
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| Synonym | More Synonyms |
| Description | L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2]. |
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| Related Catalog | |
| In Vitro | L-689560 is a 2-carboxytetrahydroquinoline antagonist[2]. |
| In Vivo | L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1] Animal Model: Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) model[1] Dosage: 1 mg/kg Administration: IP Result: Significantly reduced the neuroprotective effect of glycine after glycine receptors. |
| References |
| Density | 1.51g/cm3 |
|---|---|
| Boiling Point | 549.1ºC at 760 mmHg |
| Melting Point | 172-173ºC |
| Molecular Formula | C17H15Cl2N3O3 |
| Molecular Weight | 380.22500 |
| Flash Point | 285.9ºC |
| Exact Mass | 379.04900 |
| PSA | 90.46000 |
| LogP | 4.72690 |
| Vapour Pressure | 6.81E-13mmHg at 25°C |
| Index of Refraction | 1.683 |
| HS Code | 2933499090 |
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| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| L-689,560 |
| 4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline |
| TRANS-2-CARBOXY-5,7-DICHLORO-4-PHENYLAMINOCARBONYLAMINO-1,2,3,4-TETRAHYDROQUINOLINE |