ATPA

Modify Date: 2024-01-04 23:38:54

ATPA Structure
ATPA structure
Common Name ATPA
CAS Number 140158-50-5 Molecular Weight 228.24500
Density 1.264g/cm3 Boiling Point 406.8ºC at 760mmHg
Molecular Formula C10H16N2O4 Melting Point N/A
MSDS Chinese Flash Point 199.9ºC

 Use of ATPA


ATPA is a selective glutamate receptor GluR5 activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively[1].

 Names

Name ATPA,(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoicacid
Synonym More Synonyms

 ATPA Biological Activity

Description ATPA is a selective glutamate receptor GluR5 activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively[1].
Related Catalog
In Vitro ATPA also activates GluR1wt, GluR1(M722S), GluR1(T700S), GluR1(T700S, M722S), GluR1(M722A) with EC50s of 62, 4.6, 97, 14, 97 μM, respectively[1].
References

[1]. Nielsen MM, et al. The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741. Mol Pharmacol. 2003 Jan;63(1):19-25.

 Chemical & Physical Properties

Density 1.264g/cm3
Boiling Point 406.8ºC at 760mmHg
Molecular Formula C10H16N2O4
Molecular Weight 228.24500
Flash Point 199.9ºC
Exact Mass 228.11100
PSA 109.58000
LogP 1.33240
Vapour Pressure 2.38E-07mmHg at 25°C
Index of Refraction 1.529

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

16,16-Dimethyl Prostaglandin E2
ATPA