eIF4A3-IN-18

Modify Date: 2024-04-03 09:39:31

eIF4A3-IN-18 structure	Common Name	eIF4A3-IN-18
	CAS Number	1402931-84-3	Molecular Weight	500.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₂₈N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of eIF4A3-IN-18

eIF4A3-IN-18 (compound 74) is a silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis[1].

Name	eIF4A3-IN-18

Description	eIF4A3-IN-18 (compound 74) is a silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
References	[1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.

Molecular Formula	C₂₉H₂₈N₂O₆
Molecular Weight	500.54

eIF4A3-IN-18

Use of eIF4A3-IN-18

Names

eIF4A3-IN-18 Biological Activity

Chemical & Physical Properties