butanedioic acid,sodium

Modify Date: 2024-01-03 15:01:53

butanedioic acid,sodium Structure
butanedioic acid,sodium structure
Common Name butanedioic acid,sodium
CAS Number 14047-56-4 Molecular Weight 141.07800
Density N/A Boiling Point 158ºC at 760mmHg
Molecular Formula C4H6NaO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of butanedioic acid,sodium


Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten‑eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research[1][2][3].

 Names

Name butanedioic acid,sodium
Synonym More Synonyms

 butanedioic acid,sodium Biological Activity

Description Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten‑eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research[1][2][3].
Related Catalog
In Vivo Succinic acid sodium (3.0 or 6.0 mg/kg, PO) increased the percentage of entries into open arms and of time spent on open arms[1]. succinic acid (3.0, 6.0, and 12.0 mg/kg, IP) caused significant increases in food intake during 5 min when compared with the vehicle[1]. Succinic acid sodium (100 mM) infused into rat colons significantly inhibits colonic cell proliferation and reduced crypt size[2].
References

[1]. Chen SW, Xin Q, Kong WX, Min L, Li JF. Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64.

[2]. Inagaki A, et al. Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats. J Nutr Sci Vitaminol (Tokyo). 2007 Aug;53(4):377-9.

[3]. Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22(4):1072.

 Chemical & Physical Properties

Boiling Point 158ºC at 760mmHg
Molecular Formula C4H6NaO4
Molecular Weight 141.07800
Exact Mass 141.01600
PSA 74.60000
Vapour Pressure 0.0165mmHg at 25°C

 Synonyms

Butanedioic acid,sodium salt (1:)
EINECS 237-884-4
Butanedioic acid,sodium salt
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