EM20-25
EM20-25 structure
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Common Name | EM20-25 | ||
|---|---|---|---|---|
| CAS Number | 141266-44-6 | Molecular Weight | 376.70800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H9ClN4O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS09 |
Signal Word | Warning | |
| Name | 5-(7-chloro-2,4-dioxo-1,5-dihydrochromeno[2,3-d]pyrimidin-5-yl)-1,3-diazinane-2,4,6-trione |
|---|---|
| Synonym | More Synonyms |
| Molecular Formula | C15H9ClN4O6 |
|---|---|
| Molecular Weight | 376.70800 |
| Exact Mass | 376.02100 |
| PSA | 157.72000 |
| LogP | 1.31280 |
|
~99%
EM20-25 CAS#:141266-44-6 |
| Literature: Figueroa-Villar; Rangel Cruz; Dos Santos Synthetic Communications, 1992 , vol. 22, # 8 p. 1159 - 1164 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
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Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.
PLoS ONE 5(3) , e9924, (2010) Current limitations of chemotherapy include toxicity on healthy tissues and multidrug resistance of malignant cells. A number of recent anti-cancer strategies aim at targeting the mitochondrial apopto... |
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The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.
J. Biol. Chem. 281 , 10066-10072, (2006) We have investigated the mitochondrial effects of BH3I-2', Chelerythrine, and HA14-1, small organic molecules that share the ability to bind the BH3 domain of BCL-2. All compounds displayed a biphasic... |
| 5-(2,4-dioxo-7-chloro-2,3,4,5-tetrahydro-1H-chromeno[2,3-d]pyrimidin-5-yl)pyrimidine-2,4,6(1H,3H,5H)-trione |
| 1,5-Dihydro-7-chloro-5-<5'-pyrimidine-2',4',6'(1'H,3'H,5'H)-trionyl>-2H-chromeno<2,3-d>pyrimidine-2,4(1H,3H)-dione |
| EM20-25 |
| Bcl-2 Inhibitor III,EM20-25 |
| 5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione |
| 5-(7-chloro-2,4-dioxo-1,3-dihydro-5H-chromeno[2,3-d]pyrimidin-5-yl)-1,3,5-trih ydropyrimidine-2,4,6-trione |