H-Gly-Pro-Gly-NH2 · HCl

Modify Date: 2024-02-06 15:23:27

H-Gly-Pro-Gly-NH2 · HCl Structure
H-Gly-Pro-Gly-NH2 · HCl structure
 Common Name H-Gly-Pro-Gly-NH2 · HCl
CAS Number 141497-12-3 Molecular Weight 264.70900
Density N/A Boiling Point N/A
Molecular Formula C9H17ClN4O3 Melting Point N/A
MSDS USA Flash Point N/A

 Use of H-Gly-Pro-Gly-NH2 · HCl


H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research[1][2][3].

 Names

Name h-gly-pro-gly-nh2 hcl
Synonym More Synonyms

 H-Gly-Pro-Gly-NH2 · HCl Biological Activity

Description H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research[1][2][3].
Related Catalog
Target

HIV (IIIB):35 μM (EC50)

HIV-2 (ROD):30 μM (EC50)

In Vitro H-Gly-Pro-Gly-NH2 (5、20 和 100 µM) 在感染 HIV-1 SF-2 的 HUT78 细胞中显示抗病毒活性[1]。 H-Gly-Pro-Gly-NH2 (100 µM) 在 ACH-2 细胞中破坏 HIV-1 病毒粒子的衣壳[1]。 H-Gly-Pro-Gly-NH2 对临床 HIV-1 的抗病毒活性[2] T215Y/F K70R M184V L74V T69D Mean IC50 (µM) 16 17 20 12 17 K103N Y181C G48V L90M V82A/T M46I/L Mean IC50 (µM) 13 21 16 18 16 17
References

[1]. Höglund S, et al. Tripeptide interference with human immunodeficiency virus type 1 morphogenesis. Antimicrob Agents Chemother. 2002 Nov;46(11):3597-605.  

[2]. Andersson E, et al. No cross-resistance or selection of HIV-1 resistant mutants in vitro to the antiretroviral tripeptide glycyl-prolyl-glycine-amide[J]. Antiviral research, 2004, 61(2): 119-124.

[3]. Balzarini J, et al. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)). Int J Biochem Cell Biol. 2004 Sep;36(9):1848-59.  

 Chemical & Physical Properties

Molecular Formula C9H17ClN4O3
Molecular Weight 264.70900
Exact Mass 264.09900
PSA 118.52000
LogP 0.06900

 Synonyms

H-Gly-Pro-Gly-NH2
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