TL-895

Modify Date: 2024-04-05 17:55:31

TL-895 structure	Common Name	TL-895
	CAS Number	1415823-49-2	Molecular Weight	447.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₆FN₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TL-895

TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively[1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research[2][3][4].

Name	TL-895

Description	TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively[1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research[2][3][4].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Target	IC50: 1.5 nM; Ki: 11.9 nM (BTK)[1]
References	[1]. Richard D Caldwell, et al. Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases. J Med Chem. 2019 Sep 12;62(17):7643-7655. [2]. Valeria Di Battista, et al. Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review. Int J Mol Sci [3]. A Study of TL-895 With Standard Available Treatment Versus Standard Available Treatment for the Treatment of COVID-19 in Patients With Cancer [4]. Study of TL-895 in Subjects With Myelofibrosis

Molecular Formula	C₂₅H₂₆FN₅O₂
Molecular Weight	447.50

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TL-895
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: TL-895
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥1400/5 mg

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TL-895

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TL-895 Biological Activity

Chemical & Physical Properties