1415823-49-2

1415823-49-2 structure

Name: TL-895
Chemical Name: TL-895
CAS Number: 1415823-49-2
Molecular Formula: C₂₅H₂₆FN₅O₂
Molecular Weight: 447.50
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
Create Date: 2022-01-06 14:33:38
Modify Date: 2024-04-05 17:55:31
TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively[1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research[2][3][4].

Name	TL-895

Description	TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively[1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research[2][3][4].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Target	IC50: 1.5 nM; Ki: 11.9 nM (BTK)[1]
References	[1]. Richard D Caldwell, et al. Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases. J Med Chem. 2019 Sep 12;62(17):7643-7655. [2]. Valeria Di Battista, et al. Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review. Int J Mol Sci [3]. A Study of TL-895 With Standard Available Treatment Versus Standard Available Treatment for the Treatment of COVID-19 in Patients With Cancer [4]. Study of TL-895 in Subjects With Myelofibrosis

Molecular Formula	C₂₅H₂₆FN₅O₂
Molecular Weight	447.50