(±)-BI-D

Modify Date: 2024-01-09 17:31:17

(±)-BI-D structure	Common Name	(±)-BI-D
	CAS Number	1416258-16-6	Molecular Weight	405.486
	Density	1.2±0.1 g/cm3	Boiling Point	587.3±50.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₂₇NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	309.0±30.1 °C

Use of (±)-BI-D

(±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.IC50 value: 2.4–2.9 μM(HIV-Luc infection of WT and Hdgfrp2 KO cells) [1]Target: integrase inhibitorin vitro: Approximately 2.4–2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160–200 nM, in Psip1 and double-KO cells [1].

Name	(±)-BI-D
Synonym	More Synonyms

Description	(±)-BI-D is a potent ALLINI(An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site.IC50 value: 2.4–2.9 μM(HIV-Luc infection of WT and Hdgfrp2 KO cells) [1]Target: integrase inhibitorin vitro: Approximately 2.4–2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160–200 nM, in Psip1 and double-KO cells [1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
References	[1]. Wang H, et al. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec;40(22):115 [2]. Fader LD, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. ACS Med Chem Lett. 2014 Apr 16;5(6):711-6.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

References

[1]. Wang H, et al. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec;40(22):115

[2]. Fader LD, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. ACS Med Chem Lett. 2014 Apr 16;5(6):711-6.

Density	1.2±0.1 g/cm3
Boiling Point	587.3±50.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₇NO₄
Molecular Weight	405.486
Flash Point	309.0±30.1 °C
Exact Mass	405.194000
LogP	5.28
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.610

[4-(3,4-Dihydro-2H-chromen-6-yl)-2-methyl-3-quinolinyl][(2-methyl-2-propanyl)oxy]acetic acid

3-Quinolineacetic acid, 4-(3,4-dihydro-2H-1-benzopyran-6-yl)-α-(1,1-dimethylethoxy)-2-methyl-

DC Chemicals Limited
China
Product Name: (±)-BI-D
Price: $400.0/10mg $1200.0/50mg $1680.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $462/10mM*1mLinDMSO

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(±)-BI-D

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