Trimipramine N-oxide
Modify Date: 2024-01-15 19:34:22
Trimipramine N-oxide structure
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Common Name | Trimipramine N-oxide | ||
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| CAS Number | 14171-70-1 | Molecular Weight | 310.43300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H26N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Trimipramine N-oxideTrimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety[1]. |
| Name | Trimipramine N-Oxide |
|---|---|
| Synonym | More Synonyms |
| Description | Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety[1]. |
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| Related Catalog | |
| Target |
IC50: 3.59 nM (hSERT), 9.35 nM (hOCT1), 9.4 nM (hDAT), 11.7 nM (hNAT), 27.4 (hOCT2)[1] |
| In Vitro | Trimipramine N-oxide (0-30 μM; 48 h) inhibits hNAT, hSERT, hDAT, hOCT1 and hOCT2 in HEK293 cells[1]. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 0-30 μM Incubation Time: 48 hours Result: Dose-dependently inhibited hNAT, hSERT, hDAT, hOCT1 and hOCT2 with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM in HEK293 cells, respectively. |
| References |
| Molecular Formula | C20H26N2O |
|---|---|
| Molecular Weight | 310.43300 |
| Exact Mass | 310.20500 |
| PSA | 32.67000 |
| LogP | 4.21950 |
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~%
Trimipramine N-oxide CAS#:14171-70-1 |
| Literature: Gowda, Narendra B.; Rao, Gopal Krishna; Ramakrishna, Ramesha A. Tetrahedron Letters, 2010 , vol. 51, # 43 p. 5690 - 5693 |
| Precursor 1 | |
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| DownStream 1 | |
| 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethylpropan-1-amine oxide |