N-Acetyl-D-galactosamine

Modify Date: 2024-01-08 12:49:53

N-Acetyl-D-galactosamine Structure
N-Acetyl-D-galactosamine structure
Common Name N-Acetyl-D-galactosamine
CAS Number 14215-68-0 Molecular Weight 221.208
Density 1.5±0.1 g/cm3 Boiling Point 595.4±50.0 °C at 760 mmHg
Molecular Formula C8H15NO6 Melting Point 158-162 °C
MSDS Chinese Flash Point 313.9±30.1 °C

 Use of N-Acetyl-D-galactosamine


N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets[1].N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin[2].

 Names

Name N-acetyl-D-galactosamine
Synonym More Synonyms

 N-Acetyl-D-galactosamine Biological Activity

Description N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets[1].N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin[2].
Related Catalog
In Vitro N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) decreases the expression of occludin mRNA and claudin-3 mRNA by 1.6% and 2.7%[1]. N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) lowers the protein expression of occludin and claudin-3 by 4.3% and 7.2%, respectively[1]. RT-PCR[1] Cell Line: IPEC-J2 cell Concentration: 50 nM Incubation Time: 4 hours Result: Observed a slight reduction in mRNA expression of occludin and claudin-3. Western Blot Analysis[1] Cell Line: IPEC-J2 cell Concentration: 50 nM Incubation Time: 4 hours Result: Alleviated the damage of tight junction expressions at protein level.
References

[1]. Zhao B, et al. N-Acetyl-d-galactosamine prevents soya bean agglutinin-induced intestinal barrier dysfunction in intestinal porcine epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019 Jul;103(4):1198-1206.

[2]. Sadanandan R, et al. Isolation, Purification and Characterisation of a D-galactose and N-acetyl-D-galactosamineSpecific Lectin from Marine Sponge Fasciospongia cavernosa. Protein Pept Lett. 2018;25(9):871-877.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 595.4±50.0 °C at 760 mmHg
Melting Point 158-162 °C
Molecular Formula C8H15NO6
Molecular Weight 221.208
Flash Point 313.9±30.1 °C
Exact Mass 221.089935
PSA 119.25000
LogP -2.48
Vapour Pressure 0.0±3.8 mmHg at 25°C
Index of Refraction 1.576
Storage condition 2~8°C

 Safety Information

Hazard Codes Xi: Irritant;
Safety Phrases S22-S24/25
WGK Germany 3

 Synonyms

N-[(3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]acetamide
EINECS 217-321-9
MFCD00065372
D-Galactopyranose, 2-(acetylamino)-2-deoxy-
N-ACETEYL-D-GALACTOSAMINIDE
N-Acetyl-D-galactosamine
2-(Acetylamino)-2-deoxy-D-galactopyranose
N-acelyl-D-glucosamine
2-Acetamido-2-deoxy-D-galactose
N-Acetylchondrosamine
N-ACETYL-D-GALACTOSAMINIDE
N-((3R,4R,5R,6R)-2,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide
2-Acetamido-2-deoxy-D-galactopyranose Hydrate
2-Acetamido-2-deoxy-D-galactopyranose
ACETYL-D-GALACTOSAMINE
N-Acetyl-D-chondrosamine Hydrate
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