LY2922470
Modify Date: 2025-08-27 11:38:53
LY2922470 structure
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Common Name | LY2922470 | ||
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| CAS Number | 1423018-12-5 | Molecular Weight | 475.599 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 689.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C28H29NO4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 370.5±31.5 °C | |
Use of LY2922470LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively. LY2922470 reduces glucose levels along with significant increases in insulin and GLP-1, is potential for the treatment of type 2 diabetes mellitus (T2DM)[1]. |
| Name | (3S)-3-[4-({5-[(8-Methoxy-3,4-dihydro-1(2H)-quinolinyl)methyl]-2-thienyl}methoxy)phenyl]-4-hexynoic acid |
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| Synonym | More Synonyms |
| Description | LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively. LY2922470 reduces glucose levels along with significant increases in insulin and GLP-1, is potential for the treatment of type 2 diabetes mellitus (T2DM)[1]. |
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| Related Catalog | |
| Target |
EC50：7 nM (human GPR40), 1 nM (mouse GPR40), 3 nM (rat GPR40)[1] |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 689.1±55.0 °C at 760 mmHg |
| Molecular Formula | C28H29NO4S |
| Molecular Weight | 475.599 |
| Flash Point | 370.5±31.5 °C |
| Exact Mass | 475.181732 |
| LogP | 5.89 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.626 |
| MFCD30489363 |
| (3S)-3-[4-({5-[(8-Methoxy-3,4-dihydro-1(2H)-quinolinyl)methyl]-2-thienyl}methoxy)phenyl]-4-hexynoic acid |
| Benzenepropanoic acid, 4-[[5-[(3,4-dihydro-8-methoxy-1(2H)-quinolinyl)methyl]-2-thienyl]methoxy]-β-1-propyn-1-yl-, (βS)- |