HBX 28258
Modify Date: 2025-08-26 13:38:06
HBX 28258 structure
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Common Name | HBX 28258 | ||
|---|---|---|---|---|
| CAS Number | 1426544-54-8 | Molecular Weight | 435.996 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H30ClN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HBX 28258HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase. |
| Name | HBX 28258 |
|---|
| Description | HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase. |
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| References | References 1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77. View Related Products by Target Deubiquitinase (DUB) |
| Molecular Formula | C26H30ClN3O |
|---|---|
| Molecular Weight | 435.996 |