1426544-54-8
1426544-54-8 structure
- Name: HBX 28258
- Chemical Name: HBX 28258
- CAS Number: 1426544-54-8
- Molecular Formula: C26H30ClN3O
- Molecular Weight: 435.996
- Create Date: 2020-01-19 16:22:55
- Modify Date: 2024-08-17 11:00:52
-
HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase.
| Name | HBX 28258 |
|---|
| Description | HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrestes HCT116 cancer cells in G1 phase. |
|---|---|
| References | References 1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77. View Related Products by Target Deubiquitinase (DUB) |
| Molecular Formula | C26H30ClN3O |
|---|---|
| Molecular Weight | 435.996 |