L-Sulforaphane
L-Sulforaphane structure
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Common Name | L-Sulforaphane | ||
|---|---|---|---|---|
| CAS Number | 142825-10-3 | Molecular Weight | 177.288 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 368.2±25.0 °C at 760 mmHg | |
| Molecular Formula | C6H11NOS2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 176.5±23.2 °C | |
Use of L-Sulforaphane(R)-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. (R)-Sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer[1][2]. |
| Name | (R)-sulforaphane |
|---|---|
| Synonym | More Synonyms |
| Description | (R)-Sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway. (R)-Sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 368.2±25.0 °C at 760 mmHg |
| Molecular Formula | C6H11NOS2 |
| Molecular Weight | 177.288 |
| Flash Point | 176.5±23.2 °C |
| Exact Mass | 177.028198 |
| PSA | 80.73000 |
| LogP | 0.23 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.567 |
| Storage condition | -20°C |
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Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE Product identifiers Product name: L-Sulforaphane CAS-No.: 142825-10-3 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances Section2. HAZARDS IDENTIFICATION Classification of the substance or mixture Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008. This substance is not classified as dangerous according to Directive 67/548/EEC. Label elements The product does not need to be labelled in accordance with EC directives or respective national laws. Other hazards - none Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms: (R)-1-Isothiocyanato-4-(methylsulfinyl)butane 4-Methylsulfinylbutyl isothiocyanate Formula: C6H11NOS2 Molecular Weight: 177,29 g/mol Section4. FIRST AID MEASURES Description of first aid measures If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. In case of skin contact Wash off with soap and plenty of water. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Most important symptoms and effects, both acute and delayed To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Indication of any immediate medical attention and special treatment needed no data available Section5. FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Sulphur oxides Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available Section6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Avoid breathing vapors, mist or gas. Environmental precautions Do not let product enter drains. Methods and materials for containment and cleaning up Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. Section7. HANDLING AND STORAGE Precautions for safe handling Normal measures for preventive fire protection. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: -20 °C Specific end uses no data available Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls General industrial hygiene practice. Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Section9. PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) AppearanceForm: viscous Colour: light yellow b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Autoignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available Section10. STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong acids, Strong bases Hazardous decomposition products Other decomposition products - no data available Section11. TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects InhalationMay be harmful if inhaled. May cause respiratory tract irritation. IngestionMay be harmful if swallowed. SkinMay be harmful if absorbed through skin. May cause skin irritation. EyesMay cause eye irritation. Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Additional Information RTECS: Not available Section12. ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available Section13. DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. Section14. TRANSPORT INFORMATION UN number ADR/RID: -IMDG: -IATA: - UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA:Not dangerous goods Transport hazard class(es) ADR/RID: -IMDG: -IATA: - Packaging group ADR/RID: -IMDG: -IATA: - Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available SECTION 15 - REGULATORY INFORMATION N/A SECTION 16 - ADDITIONAL INFORMATION N/A |
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S23-S24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2930909090 |
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L-Sulforaphane CAS#:142825-10-3 |
| Literature: Journal of Organic Chemistry, , vol. 59, # 3 p. 597 - 601 |
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L-Sulforaphane CAS#:142825-10-3 |
| Literature: Journal of Organic Chemistry, , vol. 59, # 3 p. 597 - 601 |
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L-Sulforaphane CAS#:142825-10-3 |
| Literature: Tetrahedron: Asymmetry, , vol. 6, # 7 p. 1569 - 1574 |
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L-Sulforaphane CAS#:142825-10-3 |
| Literature: Tetrahedron: Asymmetry, , vol. 6, # 7 p. 1569 - 1574 |
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L-Sulforaphane CAS#:142825-10-3 |
| Literature: Journal of Organic Chemistry, , vol. 59, # 3 p. 597 - 601 |
|
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L-Sulforaphane CAS#:142825-10-3 |
| Literature: Tetrahedron: Asymmetry, , vol. 6, # 7 p. 1569 - 1574 |
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L-Sulforaphane CAS#:142825-10-3 |
| Literature: Chemistry - A European Journal, , vol. 3, # 5 p. 713 - 716 |
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L-Sulforaphane CAS#:142825-10-3 |
| Literature: Helvetica Chimica Acta, , vol. 31, p. 1497,1500 |
![1-isothiocyanato-4-[(S)-methylsulfinyl]butane structure](https://image.chemsrc.com/caspic/198/155320-20-0.png)
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells.
Int. J. Mol. Med. 36 , 53-64, (2015) Sulforaphane, a natural isothiocyanate compound found in cruciferous vegetables, has been shown to exert cardioprotective effects during ischemic heart injury. However, the effects of sulforaphane on ... |
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In vitro metabolic conversion of the organic breakdown products of glucosinolate to goitrogenic thiocyanate anion.
J. Sci. Food Agric. 95 , 2244-51, (2015) Glucosinolates are abundant in Brassicaceae vegetables, and they are degraded into various organic breakdown products (BPs) (R-CN, -NCS and -SCN) by myrosinase when plant tissues are damaged. This stu... |
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Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations.
Cancer Res. 75 , 4817-29, (2015) Pharmacologic activation of the transcription factor NRF2 has been suggested to offer a strategy for cancer prevention. In this study, we present evidence from murine tumorigenesis experiments suggest... |
| UNII:41684WL1GL |
| 1-Isothiocyanato-4-(methylsulfinyl)butane |
| SULFORAPHANE, (±)- |
| 4-Isothiocyanatobutyl methyl sulfoxide |
| 4-Methylsulfinylbutyl isothiocyanate |
| 1-Isothiocyanato-4-[(R)-methylsulfinyl]butane |
| 4-(Methylsulfinyl)butyl isothiocyanate |
| Butane, 1-isothiocyanato-4-[(R)-(1R)-methylsulfinyl]- |
| Butane, 1-isothiocyanato-4-(methylsulfinyl)- |
| (R)-sulforaphane |
| MFCD09039283 |
| DL-Sulforaphane |
| (R)-1-isothiocyanato-4-(methylsulfinyl)butane |
| Sulforaphane |
| (-)-Sulforaphane |
| L-Sulforaphane |
| 4-isothiocyanatobutyl methyl (R)-sulfoxide |
| (R)-1-Isothiocyanato-4-(methylsulfinyl)butane,4-Methylsulfinylbutyl isothiocyanate |
| SCN4SO&1 |