YH16899

Modify Date: 2024-01-10 17:40:22

YH16899 Structure
YH16899 structure
Common Name YH16899
CAS Number 1428623-14-6 Molecular Weight 444.375
Density 1.5±0.1 g/cm3 Boiling Point 569.8±60.0 °C at 760 mmHg
Molecular Formula C19H13F5N2O3S Melting Point N/A
MSDS N/A Flash Point 298.4±32.9 °C

 Use of YH16899


YH16899 binds Lysyl-tRNA synthetase (KRS), and inhibits membrane translocation of KRS. YH16899 impares the interaction of KRS with 67LR. YH16899 inhibits tumor metastasis in mouse models[1].

 Names

Name 2-[(2Z)-5,6-Difluoro-2-{[3-(trifluoromethyl)benzoyl]imino}-1,3-benzothiazol-3(2H)-yl]butanoic acid
Synonym More Synonyms

 YH16899 Biological Activity

Description YH16899 binds Lysyl-tRNA synthetase (KRS), and inhibits membrane translocation of KRS. YH16899 impares the interaction of KRS with 67LR. YH16899 inhibits tumor metastasis in mouse models[1].
Related Catalog
References

[1]. Kim DG, et al. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nat Chem Biol. 2014 Jan;10(1):29-34.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 569.8±60.0 °C at 760 mmHg
Molecular Formula C19H13F5N2O3S
Molecular Weight 444.375
Flash Point 298.4±32.9 °C
Exact Mass 444.056702
LogP 5.08
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.593

 Synonyms

3(2H)-Benzothiazoleacetic acid, α-ethyl-5,6-difluoro-2-[[3-(trifluoromethyl)benzoyl]imino]-, (2Z)-
2-[(2Z)-5,6-Difluoro-2-{[3-(trifluoromethyl)benzoyl]imino}-1,3-benzothiazol-3(2H)-yl]butanoic acid