N4-Acetylcytidine triphosphate

Modify Date: 2025-08-23 22:43:08

N4-Acetylcytidine triphosphate Structure
N4-Acetylcytidine triphosphate structure
Common Name N4-Acetylcytidine triphosphate
CAS Number 1428903-57-4 Molecular Weight 525.19
Density N/A Boiling Point N/A
Molecular Formula C11H18N3O15P3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N4-Acetylcytidine triphosphate


N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression[1].

 Names

Name N4-Acetylcytidine triphosphate

 N4-Acetylcytidine triphosphate Biological Activity

Description N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression[1].
Related Catalog
Target

NLRP3[1]

In Vitro N4-Acetylcytidine (0.3  mM or 1.0  mM) upregulates NF-κB and NLRP3 expression BV2 microglia, and this calls for HMGB1 expression and release[1].
References

[1]. Duan J, et al. N4-acetylcytidine is required for sustained NLRP3 inflammasome activation via HMGB1 pathway in microglia. Cell Signal. 2019 Mar 7;58:44-52.

 Chemical & Physical Properties

Molecular Formula C11H18N3O15P3
Molecular Weight 525.19
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