N4-Acetylcytidine triphosphate

Modify Date: 2024-01-11 08:57:30

N4-Acetylcytidine triphosphate structure	Common Name	N4-Acetylcytidine triphosphate
	CAS Number	1428903-57-4	Molecular Weight	525.19
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₈N₃O₁₅P₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N4-Acetylcytidine triphosphate

N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression[1].

Name	N4-Acetylcytidine triphosphate

Description	N4-Acetylcytidine triphosphate is a endogenous nucleoside metabolite from the degradation of tRNA, primes and activates NLRP3 inflammation by inducing HMGB1 expression[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NLRP3[1]
In Vitro	N4-Acetylcytidine (0.3  mM or 1.0  mM) upregulates NF-κB and NLRP3 expression BV2 microglia, and this calls for HMGB1 expression and release[1].
References	[1]. Duan J, et al. N4-acetylcytidine is required for sustained NLRP3 inflammasome activation via HMGB1 pathway in microglia. Cell Signal. 2019 Mar 7;58:44-52.

Molecular Formula	C₁₁H₁₈N₃O₁₅P₃
Molecular Weight	525.19

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