3-Pyrrolidinone,5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-,(5S)-

Modify Date: 2024-09-04 12:14:35

3-Pyrrolidinone,5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-,(5S)- structure	Common Name	3-Pyrrolidinone,5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-,(5S)-
	CAS Number	1430738-05-8	Molecular Weight	580.86
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₄₈N₂O₇Si₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3-Pyrrolidinone,5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[5-methoxy-2-nitro-4-[[tris(1-methylethyl)silyl]oxy]benzoyl]-,(5S)-

Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.

Name	(S)-5-(((tert-Butyldimethylsilyl)oxy)methyl)-1-(5-methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoyl)pyrrolidin-3-one

Description	Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
References	[1]. Howard, et al. Process for the preparation of intermediates useful for the synthesis of pyrrolobenzodiazepine dimers. World Intellectual Property Organization, WO2013053872 A1. 2013-04-18. [2]. Tiberghien AC, et al. Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016;7(11):983-987. Published 2016 May 24.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker

References

[1]. Howard, et al. Process for the preparation of intermediates useful for the synthesis of pyrrolobenzodiazepine dimers. World Intellectual Property Organization, WO2013053872 A1. 2013-04-18.

[2]. Tiberghien AC, et al. Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016;7(11):983-987. Published 2016 May 24.