Rabacfosadine succinate

Modify Date: 2024-02-17 23:24:43

Rabacfosadine succinate Structure
Rabacfosadine succinate structure
Common Name Rabacfosadine succinate
CAS Number 1431856-99-3 Molecular Weight 644.61400
Density N/A Boiling Point N/A
Molecular Formula C25H41N8O10P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Rabacfosadine succinate


Rabacfosadine (GS-9219) succinate, a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells[1].

 Names

Name butanedioic acid,ethyl (2S)-2-[[2-[2-amino-6-(cyclopropylamino)purin-9-yl]ethoxymethyl-[[(2S)-1-ethoxy-1-oxopropan-2-yl]amino]phosphoryl]amino]propanoate
Synonym More Synonyms

 Rabacfosadine succinate Biological Activity

Description Rabacfosadine (GS-9219) succinate, a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells[1].
Related Catalog
References

[1]. Reiser H, et al. GS-9219--a novel acyclic nucleotide analogue withpotent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma.Clin Cancer Res. 2008 May 1;14(9):2824-32.  

[2]. De Clercq E. Tanovea® for the treatment of lymphoma in dogs. Biochem Pharmacol. 2018 Aug;154:265-269.  

 Chemical & Physical Properties

Molecular Formula C25H41N8O10P
Molecular Weight 644.61400
Exact Mass 644.26800
PSA 269.75000
LogP 1.95310

 Synonyms

GS-9219 succinate
UNII-3L28LG748I
L-Alanine,N,N'-(((2-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis-,diethyl ester,succinic acid salt (1:1)