![]() S-methyl-KE-298 structure
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Common Name | S-methyl-KE-298 | ||
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CAS Number | 143584-75-2 | Molecular Weight | 252.329 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 457.2±45.0 °C at 760 mmHg | |
Molecular Formula | C13H16O3S | Melting Point | N/A | |
MSDS | N/A | Flash Point | 230.3±28.7 °C |
Use of S-methyl-KE-298S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. |
Name | S-methyl-KE-298 |
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Synonym | More Synonyms |
Description | S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. |
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Related Catalog | |
In Vitro | S-methyl-KE-298 is a methyl conjugate of deacetyl-KE-298 is plasma[1]. In vitro protein binding of KE-298 and its plasma metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2), is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively[2]. KE-298 blocks this IL-1β-induced pro-MMP-2 activation and MT1-MMP expression, but does not affect IL-1β-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells. KE-298 inhibits MMP-1 production from rheumatoid arthritis (RA) synovial cells by affecting a transcription factor, AP-1. KE-298 inhibits the basal levels of MT1-MMP expression of unstimulated rheumatoid synovial cells[3]. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 457.2±45.0 °C at 760 mmHg |
Molecular Formula | C13H16O3S |
Molecular Weight | 252.329 |
Flash Point | 230.3±28.7 °C |
Exact Mass | 252.082016 |
LogP | 2.84 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.565 |
Storage condition | 2-8℃ |
Benzenebutanoic acid, 4-methyl-α-[(methylthio)methyl]-γ-oxo- |
4-(4-Methylphenyl)-2-[(methylsulfanyl)methyl]-4-oxobutanoic acid |
4-(4-methylphenyl)-2-methylthiomethyl-4-oxobutanoic acid |