Aldesulfone Sodium

Modify Date: 2024-01-02 08:56:59

Aldesulfone Sodium Structure
Aldesulfone Sodium structure
Common Name Aldesulfone Sodium
CAS Number 144-75-2 Molecular Weight 448.44500
Density N/A Boiling Point 857.3ºC at 760 mmHg
Molecular Formula C14H14N2Na2O6S3 Melting Point N/A
MSDS N/A Flash Point 472.3ºC

 Use of Aldesulfone Sodium


Sulfoxone (Aldesulfone) disodium is an orally active sulphonamide antibiotic that is used against leprosy. Sulfoxone disodium can also be used in study of dermatitis herpetiformis[1][2].

 Names

Name disodium,[4-[4-(sulfinatomethylamino)phenyl]sulfonylanilino]methanesulfinate
Synonym More Synonyms

 Aldesulfone Sodium Biological Activity

Description Sulfoxone (Aldesulfone) disodium is an orally active sulphonamide antibiotic that is used against leprosy. Sulfoxone disodium can also be used in study of dermatitis herpetiformis[1][2].
Related Catalog

 Chemical & Physical Properties

Boiling Point 857.3ºC at 760 mmHg
Molecular Formula C14H14N2Na2O6S3
Molecular Weight 448.44500
Flash Point 472.3ºC
Exact Mass 447.98100
PSA 185.26000
LogP 3.97460
Vapour Pressure 2.64E-31mmHg at 25°C
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB0390100
CHEMICAL NAME :
Methanesulfinic acid, (sulfonylbis(p-phenyleneimino))di-, disodium salt
CAS REGISTRY NUMBER :
144-75-2
LAST UPDATED :
199606
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C14-H14-N2-O6-S3.2Na
MOLECULAR WEIGHT :
448.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 70,1268,1948
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 61,617,1939
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18900 mg/kg/21D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945

 Safety Information

HS Code 2930909090

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Sodium sulfoxone
Aldapsone
Diazon
(4,4'-sulfonyl-dianilino)-bis-methanesulfinic acid,disodium-salt
Adesulfone sodium
(4,4'-Sulfonyl-dianilino)-bis-methansulfinsaeure,Dinatrium-Salz
Diamidin
Novotrone
Aldesulfone [Sodium]
SULFOXONE SODIUM
Diasone