TWIK-1/TREK-1-IN-2

Modify Date: 2024-01-16 13:06:25

TWIK-1/TREK-1-IN-2 structure	Common Name	TWIK-1/TREK-1-IN-2
	CAS Number	1440532-32-0	Molecular Weight	386.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₉F₃N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TWIK-1/TREK-1-IN-2

TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant[1].

Name	TWIK-1/TREK-1-IN-2

Description	TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.

Molecular Formula	C₂₀H₂₉F₃N₂O₂
Molecular Weight	386.45

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