Fmoc-L-Lys(4-N3-Z)-OH

Modify Date: 2025-09-21 09:06:37

Fmoc-L-Lys(4-N3-Z)-OH Structure
Fmoc-L-Lys(4-N3-Z)-OH structure
Common Name Fmoc-L-Lys(4-N3-Z)-OH
CAS Number 1446511-14-3 Molecular Weight 543.57
Density N/A Boiling Point N/A
Molecular Formula C29H29N5O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fmoc-L-Lys(4-N3-Z)-OH


Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition[1][2].

 Names

Name Fmoc-L-Lys(4-N3-Z)-OH

 Fmoc-L-Lys(4-N3-Z)-OH Biological Activity

Description Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition[1][2].
Related Catalog
References

[1]. Ge Y, et al. A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells. Chem Sci. 2016 Dec 1;7(12):7055-7060.

[2]. Wesalo JS, et al. Phosphine-Activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylation. Chembiochem. 2020 Jan 15;21(1-2):141-148.

 Chemical & Physical Properties

Molecular Formula C29H29N5O6
Molecular Weight 543.57
InChIKey RSWJAKDWNDKFAB-SANMLTNESA-N
SMILES [N-]=[N+]=Nc1ccc(COC(=O)NCCCCC(NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
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