Selonsertib(GS-4997)
Modify Date: 2025-08-22 20:20:33
Selonsertib(GS-4997) structure
|
Common Name | Selonsertib(GS-4997) | ||
|---|---|---|---|---|
| CAS Number | 1448428-04-3 | Molecular Weight | 445.492 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H24FN7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Selonsertib(GS-4997)Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07. |
| Name | Selonsertib |
|---|---|
| Synonym | More Synonyms |
| Description | Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07. |
|---|---|
| Related Catalog | |
| Target |
ASK1:8.3 (pIC50) |
| In Vitro | Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis[1]. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H24FN7O |
| Molecular Weight | 445.492 |
| Exact Mass | 445.202637 |
| LogP | 3.17 |
| Index of Refraction | 1.704 |
| Storage condition | -20℃ |
| selonsertib |
| Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- |
| UNII:NS3988A2TC |
| 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-[6-(4-isopropyl-4H-1,2,4-triazol-3-yl)-2-pyridinyl]-4-methylbenzamide |
| GS-4997 |