1448428-04-3

1448428-04-3 structure

Name: Selonsertib(GS-4997)
Chemical Name: Selonsertib
CAS Number: 1448428-04-3
Molecular Formula: C₂₄H₂₄FN₇O
Molecular Weight: 445.492
Catalog: Signaling Pathways MAPK/ERK Pathway MAP3K
Create Date: 2018-03-25 08:00:00
Modify Date: 2024-01-02 12:42:43
Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07.

Name	Selonsertib
Synonyms	selonsertib Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- UNII:NS3988A2TC 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-[6-(4-isopropyl-4H-1,2,4-triazol-3-yl)-2-pyridinyl]-4-methylbenzamide GS-4997

Description	Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAP3K Research Areas >> Cancer
Target	ASK1:8.3 (pIC50)
In Vitro	Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis[1]. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain[2].
References	[1]. Lanier M, et al. Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320. [2]. Lin JH, et al. Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33.