JPI-289

Modify Date: 2024-01-19 20:29:08

JPI-289 Structure
JPI-289 structure
 Common Name JPI-289
CAS Number 1449233-60-6 Molecular Weight 452.373
Density N/A Boiling Point N/A
Molecular Formula C19H31Cl2N3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JPI-289


Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke. Stroke Phase 2 Clinical

 Names

Name Amelparib hydrochloric hydrate

 JPI-289 Biological Activity

Description Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke. Stroke Phase 2 Clinical
References References 1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679. 2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6. View Related Products by Target PARP Stroke

 Chemical & Physical Properties

Molecular Formula C19H31Cl2N3O5
Molecular Weight 452.373
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Chemsrc provides JPI-289(CAS#:1449233-60-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of JPI-289 are included as well.>> amp version: JPI-289

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