Tipepidine hydrochloride
Modify Date: 2024-01-07 17:31:35
Tipepidine hydrochloride structure
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Common Name | Tipepidine hydrochloride | ||
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| CAS Number | 1449686-84-3 | Molecular Weight | 311.89 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H18ClNS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tipepidine hydrochlorideTipepidine hydrochloride reversibly inhibits on dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) to activate VTA dopamine neuron, with an IC50 of 7.0 μM[1]. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect[2]. |
| Name | Tipepidine hydrochloride |
|---|
| Description | Tipepidine hydrochloride reversibly inhibits on dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) to activate VTA dopamine neuron, with an IC50 of 7.0 μM[1]. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect[2]. |
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| Related Catalog | |
| Target |
IC50: 7.0 μM (dopamine D2 receptor)[1] |
| In Vivo | Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats[2]. Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old) [2] Dosage: 10, 20 and 40 mg/kg Administration: I.p.; 0.5, 5, 23 hours Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats. |
| References |
| Molecular Formula | C15H18ClNS2 |
|---|---|
| Molecular Weight | 311.89 |
| Storage condition | -20°C |