Coproporphyrin III

Modify Date: 2024-01-05 19:43:09

Coproporphyrin III Structure
Coproporphyrin III structure
Common Name Coproporphyrin III
CAS Number 14643-66-4 Molecular Weight 654.71
Density 1.366 g/cm3 Boiling Point 1258ºC at 760 mmHg
Molecular Formula C36H38N4O8 Melting Point N/A
MSDS N/A Flash Point 714.6ºC

 Use of Coproporphyrin III


Coproporphyrin III is a porphyrin derivative.

 Names

Name coproporphyrin III
Synonym More Synonyms

 Coproporphyrin III Biological Activity

Description Coproporphyrin III is a porphyrin derivative.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Coproporphyrin III methyl ester is repeatedly isolated in considerable amount from both feces and urine. A great increase of coproporphyrin III excretion is unaccompanied by symptoms or signs of porphyria, metal or chemical poisoning or liver disease[1]. Primary cultures of chick embryo hepatocytes have been used to study the mechanism by which chemicals cause accumulation of intermediates of the heme synthetic pathway. In the presence of the porphyrin precursor, 5-aminolevulinate (ALA), addition of insulin causes a striking increase in accumulation of uroporphyrin I and coproporphyrin III. Antioxidants abolishes the uroporphyrin I accumulation and increases coproporphyrin III[2].
In Vivo Urinary DMA and porphyrin profile can be used as an early warning biomarker for chronic MMA exposure before the onset of cancer. After 4 weeks the level of coproporphyrin III concentration significantly increases in all the treatment groups compared to the control[3].
References

[1]. Watson CJ, et al. Studies of coproporphyrin. iii. idiopathic coproporphyrinuria; a hitherto unrecognized form characterized by lack of symptoms in spite of the excretion of large amounts of coproporphyrin. J Clin Invest. 1949 May;28(3):465-8.

[2]. Trask HW, et al. Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures. Arch Biochem Biophys. 2005 Jul 1;439(1):1-11.

[3]. Krishnamohan M, et al. Urinary arsenic and porphyrin profile in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMAIII) for two years. Toxicol Appl Pharmacol. 2007 Oct 1;224(1):89-97.

 Chemical & Physical Properties

Density 1.366 g/cm3
Boiling Point 1258ºC at 760 mmHg
Molecular Formula C36H38N4O8
Molecular Weight 654.71
Flash Point 714.6ºC
PSA 205.50000
LogP 4.69760
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.638
Storage condition 2-8℃

 MSDS


Section 1: Product Identification
Chemical Name:Coproporphyrin III dihydrochloride
CAS Registry Number:14643-66-4
Formula:C36H38N4O8.2HCl
EINECS Number:none
Chemical Family:porphine (porphyrin) ligand
Synonym:None

Section 2: Composition and Information on Ingredients
IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL)
Title Compound14643-66-4100%no datano data

Section 3: Hazards Identification
Emergency Overview:No particular hazard associated with this material.
Primary Routes of Exposure:Ingestion, inhalation
Eye Contact:May cause slight to mild irritation of the eyes.
Skin Contact:May cause slight to mild irritation of the skin.
Inhalation:May be irritating to the nose, mucous membranes and respiratory tract.
Ingestion:No specific information is available on the physiological effects of ingestion.
Acute Health Affects:May be irritating to skin, eyes and respiratory tract.
Chronic Health Affects:No information available on long-term chronic effects.
NTP:No
IARC:No
OSHA:No

SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

SECTION 5: Fire Fighting Measures
Flash Point:no data
Autoignition Temperature:none
Explosion Limits:none
Extinguishing Medium:carbon dioxide, dry powder or foam
If this material is involved in a fire, fire fighters should be equipped with a NIOSH approved, positive pressure
Special Fire Fighting Procedures:
self contained breathing apparatus and full protective clothing.
Hazardous Combustion andIf involved in a fire this material may emit toxic organic fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

SECTION 6: Accidental Release Measures
Spill and Leak Procedures:Small spills can be mixed with vermiculite or sodium carbonate and swept up.

SECTION 7: Handling and Storage
Handling and Storage:Store in a tightly sealed container. Keep away from heat and direct sunlight.

SECTION 8: Exposure Controls and Personal Protection
Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection:Wear protective clothing and gloves.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection:No additional protection required.

SECTION 9: Physical and Chemical Properties
Color and Form:purple xtl.
Molecular Weight:727.64
Melting Point:no data
Boiling Point:no data
Vapor Pressure:no data
Specific Gravity:no data
Odor:none
Solubility in Water:soluble

SECTION 10: Stability and Reactivity
Stability:air and moisture stable solid
Hazardous Polymerization:no hazardous polymerization
Conditions to Avoid:none
Incompatibility:oxidizing agents
Decomposition Products:carbon dioxide, carbon monoxide, nitrogen oxides, and organic fumes

SECTION 11: Toxicological Information
RTECS Data:No information available in the RTECS files.
Carcinogenic Effects:No data available
Mutagenic Effects:No data available
Tetratogenic Effects:No data available

SECTION 12: Ecological Information
Ecological Information:No information available

SECTION 13: Disposal Considerations
Disposal:Dispose of according to local, state and federal regulations.

SECTION 14: Transportation
Shipping Name (CFR):Non-hazardous
Hazard Class (CFR):NA
Additional Hazard Class (CFR):NA
Packaging Group (CFR):NA
UN ID Number (CFR):NA
Shipping Name (IATA):Non-hazardous
Hazard Class (IATA):NA
Additional Hazard Class (IATA):NA
Packaging Group (IATA):NA
UN ID Number (IATA):NA

SECTION 15: Regulatory Information
TSCA:Not listed in the TSCA inventory.
SARA (Title 313):Not reportable under SARA Title 313
Second Ingredient:none


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Synonyms

3,3',3'',3'''-(3,8,13,17-tetramethyl-porphyrin-2,7,12,18-tetrayl)-tetra-propionic acid
COPROPORPHYRIN III DIHYDROCHLORIDE
3,3',3'',3'''-(3,8,13,17-Tetramethyl-porphyrin-2,7,12,18-tetrayl)-tetra-propionsaeure
3,3',3'',3'''-(3,8,13,17-tetramethyl-21H,23H-porphine-2,7,12,18-tetrayl)-tetrakis-propionic acid
CoproporphyrinIII Dihyrochloride
2,7,12,18-Tetramethyl-21H,23H-porphyrin-3,8,13,17-tetrapropionic acid
coproporphyrin
Coproporphyrin III
Coproporphyrin dihydrochloride
coproporphyriniii2HCl
3,8,13,17-tetramethylporphyrin-2,7,12,18-tetrapropanoic acid
3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,7,12,18-TETRAPROPIONIC ACID DIHYDROCHLORIDE
Koproporphyrin III
Coproporphyrin III dihydrochloride,3,8,13,17-Tetramethyl-21H,23H-porphine-2,7,12,18-tetrapropionic acid dihydrochloride
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