TAK-448 acetate

Modify Date: 2024-01-03 18:22:06

TAK-448 acetate structure	Common Name	TAK-448 acetate
	CAS Number	1470374-22-1	Molecular Weight	1285.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₀H₈₄N₁₆O₁₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TAK-448 acetate

TAK-448 acetate (MVT-602 acetate) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM[1].

Name	TAK-448 acetate

Description	TAK-448 acetate (MVT-602 acetate) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 460 pM (KISS1R)[1] EC50: 632 pM (KISS1R)[1]
In Vivo	TAK-448 acetate (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model[2]. Animal Model: Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats) Dosage: 0.01, 0.03, 0.3, 3 mg/kg Administration: Given i.h.; dosings on day 0 and 28 Result: Had greater anti-tumor effects in VCaP xenograft model.
References	[1]. Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly PotentTestosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59(19):8804-8811. [2]. Ishikawa K,et al. Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitiveprostate cancer model. Eur J Pharmacol. 2018 Jun 5;828:126-134.

Molecular Formula	C₆₀H₈₄N₁₆O₁₆
Molecular Weight	1285.41
Storage condition	2-8℃