TT 232
Modify Date: 2026-06-30 19:06:34
TT 232 structure
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Common Name | TT 232 | ||
|---|---|---|---|---|
| CAS Number | 147159-51-1 | Molecular Weight | 947.1 | |
| Density | 1.42g/cm3 | Boiling Point | 1409.4ºC at 760mmHg | |
| Molecular Formula | C45H58N10O9S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 806.2ºC | |
Use of TT 232TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent[1][2][4]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene |
|---|
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent[1][2][4]. |
|---|---|
| Related Catalog | |
| Target |
SSTR1 SSTR4 |
| In Vitro | TT-232 (10 μg/mL, 48 h) induces apoptosis in human colon (HT-29 and SW620), pancreatic (818), leukemia (K-562), melanoma (WM 938/B, M-1 and EP) and lymphoma (HT-58) tumor cell lines[1]. TT-232 (20-30 μg/mL, 24 h) shows antiproliferative effect on various human tumor cell lines[2]. Cell Viability Assay[2] Cell Line: MCF7, PC-3, P818, K-562, 4-1ST, ect. Concentration: 20-30 μg/mL Incubation Time: 24 h Result: Inhibited cell proliferation by 87%, 90%, 98%, 95%, respectively. |
| In Vivo | TT-232 (15-750 μg/kg/day, twice a day) inhibits tumor growth in mice transplanted with Colon 26 cell[2]. TT-232 (0.6 or 15 μg/kg s.c or i.p.) shows antitumor effect on P-388 rodent lymphocytic leukemia tumor mice[3]. TT-232 (7.5-20 μg/kg, i.v.) inhibits Carrageenin-induced paw oedema in rats[4]. Animal Model: Mice transplanted with Colon 26 cell [2]. Dosage: 15, 150, 750 μg/kg/day Administration: Intraperitoneal injection (i.p.) Result: Reached 70% tumor inhibition at 750 μg/kg. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.42g/cm3 |
|---|---|
| Boiling Point | 1409.4ºC at 760mmHg |
| Molecular Formula | C45H58N10O9S2 |
| Molecular Weight | 947.1 |
| Flash Point | 806.2ºC |
| Exact Mass | 946.38296581 |
| PSA | 18.46000 |
| LogP | 6.03880 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.69 |
| InChIKey | SNAJPQVDGYDQSW-DYCFWDQMSA-N |
| SMILES | C[C@H]([C@@H](C(=O)N)NC(=O)[C@@H]1CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)[C@@H](CC5=CC=CC=C5)N)O |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Antiproliferative activity against human SW480 cells at 25 uM by MTT assay
Source: ChEMBL
Target: SW480
External Id: CHEMBL942229
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Name: Antiproliferative activity against human SW480 cells at 10 uM by MTT assay
Source: ChEMBL
Target: SW480
External Id: CHEMBL942228
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Name: Antiproliferative activity against human SW480 cells at 50 uM by MTT assay
Source: ChEMBL
Target: SW480
External Id: CHEMBL942230
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Name: Antiproliferative activity against human A431 cells at 10 uM by MTT assay
Source: ChEMBL
Target: A-431
External Id: CHEMBL942225
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Name: Antiproliferative activity against human A431 cells at 50 uM by MTT assay
Source: ChEMBL
Target: A-431
External Id: CHEMBL942227
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Name: Antiproliferative activity against human A431 cells at 25 uM by MTT assay
Source: ChEMBL
Target: A-431
External Id: CHEMBL942226
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This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the Chinese name of 147159-51-1? |
| A: Chinese name of 147159-51-1 is 147159-51-1. |
| Q: What is the CAS number of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene? |
| A: CAS number of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene is 147159-51-1. |
| Q: What is the polar surface area (PSA) of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene? |
| A: Polar surface area (PSA) of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene is 18.46000. |
| Q: What is the SMILES notation of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene? |
| A: SMILES notation of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene is C[C@H]([C@@H](C(=O)N)NC(=O)[C@@H]1CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)[C@@H](CC5=CC=CC=C5)N)O. |
| Q: What is the InChIKey of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene? |
| A: InChIKey of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene is SNAJPQVDGYDQSW-DYCFWDQMSA-N. |
| Q: What is the LogP of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene? |
| A: LogP of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene is 6.03880. |
| Q: What is the molecular weight of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene? |
| A: Molecular weight of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene is 947.1. |
| Q: What is the English name of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene? |
| A: The English name of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene is 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene. |
| Q: What is the molecular formula of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene? |
| A: Molecular formula of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene is C45H58N10O9S2. |
| Q: What are the uses of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene? |
| A: Main uses of 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene: TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent[1][2][4]. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |