TT 232
Modify Date: 2025-08-21 20:30:38
TT 232 structure
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Common Name | TT 232 | ||
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| CAS Number | 147159-51-1 | Molecular Weight | 328.48800 | |
| Density | 1.42g/cm3 | Boiling Point | 1409.4ºC at 760mmHg | |
| Molecular Formula | C22H32O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 806.2ºC | |
Use of TT 232TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent[1][2][4]. |
| Name | 1-methoxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene |
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| Description | TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent[1][2][4]. |
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| Related Catalog | |
| Target |
SSTR1 SSTR4 |
| In Vitro | TT-232 (10 μg/mL, 48 h) induces apoptosis in human colon (HT-29 and SW620), pancreatic (818), leukemia (K-562), melanoma (WM 938/B, M-1 and EP) and lymphoma (HT-58) tumor cell lines[1]. TT-232 (20-30 μg/mL, 24 h) shows antiproliferative effect on various human tumor cell lines[2]. Cell Viability Assay[2] Cell Line: MCF7, PC-3, P818, K-562, 4-1ST, ect. Concentration: 20-30 μg/mL Incubation Time: 24 h Result: Inhibited cell proliferation by 87%, 90%, 98%, 95%, respectively. |
| In Vivo | TT-232 (15-750 μg/kg/day, twice a day) inhibits tumor growth in mice transplanted with Colon 26 cell[2]. TT-232 (0.6 or 15 μg/kg s.c or i.p.) shows antitumor effect on P-388 rodent lymphocytic leukemia tumor mice[3]. TT-232 (7.5-20 μg/kg, i.v.) inhibits Carrageenin-induced paw oedema in rats[4]. Animal Model: Mice transplanted with Colon 26 cell [2]. Dosage: 15, 150, 750 μg/kg/day Administration: Intraperitoneal injection (i.p.) Result: Reached 70% tumor inhibition at 750 μg/kg. |
| Density | 1.42g/cm3 |
|---|---|
| Boiling Point | 1409.4ºC at 760mmHg |
| Molecular Formula | C22H32O2 |
| Molecular Weight | 328.48800 |
| Flash Point | 806.2ºC |
| Exact Mass | 328.24000 |
| PSA | 18.46000 |
| LogP | 6.03880 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.69 |
| InChIKey | SNAJPQVDGYDQSW-DYCFWDQMSA-N |
| SMILES | CC(O)C(NC(=O)C1CSSCC(NC(=O)C(N)Cc2ccccc2)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CCCCN)C(=O)N1)C(N)=O |