TAK-915
Modify Date: 2024-01-14 14:24:30
TAK-915 structure
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Common Name | TAK-915 | ||
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| CAS Number | 1476727-50-0 | Molecular Weight | 458.364 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 651.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C19H18F4N4O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 347.5±31.5 °C | |
Use of TAK-915TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM; dispalys 4100-fold selectivity over PDE1A, and >20,000-fold over other PDE isoforms; robustly increased cGMP levels in the rat brain, attenuates MK-801-induced episodic memory deficits in rats. Schizophrenia Phase 1 Clinical |
| Name | N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide |
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| Synonym | More Synonyms |
| Description | TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM; dispalys 4100-fold selectivity over PDE1A, and >20,000-fold over other PDE isoforms; robustly increased cGMP levels in the rat brain, attenuates MK-801-induced episodic memory deficits in rats. Schizophrenia Phase 1 Clinical |
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| References | References 1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702. View Related Products by Target Phosphodiesterase (PDE) Schizophrenia |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 651.0±55.0 °C at 760 mmHg |
| Molecular Formula | C19H18F4N4O5 |
| Molecular Weight | 458.364 |
| Flash Point | 347.5±31.5 °C |
| Exact Mass | 458.121338 |
| LogP | 1.78 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.539 |
| Pyrido[2,3-b]pyrazine-4(1H)-carboxamide, N-[(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl]-2,3-dihydro-7-methoxy-2-oxo- |
| N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide |