Rifamycin sodium

Modify Date: 2024-01-02 18:52:00

Rifamycin sodium Structure
Rifamycin sodium structure
Common Name Rifamycin sodium
CAS Number 14897-39-3 Molecular Weight 719.750
Density 1.35g/cm3 Boiling Point 862.1ºC at 760mmHg
Molecular Formula C37H46NNaO12 Melting Point >215°C (dec.)
MSDS Chinese USA Flash Point 475.2ºC

 Use of Rifamycin sodium


Rifamycin sodium (Rifamycin SV monosodium) belongs to the family of ansamycin antibiotics and has been isolated from the fermentation of A. mediterranei or its mutants. Rifamycin sodium displays a broad spectrum of antibiotic activity against Gram-positive and, to a lesser extent, Gram-negative bacteria[1].

 Names

Name Rifamycin sodium salt
Synonym More Synonyms

 Rifamycin sodium Biological Activity

Description Rifamycin sodium (Rifamycin SV monosodium) belongs to the family of ansamycin antibiotics and has been isolated from the fermentation of A. mediterranei or its mutants. Rifamycin sodium displays a broad spectrum of antibiotic activity against Gram-positive and, to a lesser extent, Gram-negative bacteria[1].
Related Catalog
References

[1]. Floss HG, et al. Rifamycin-mode of action, resistance, and biosynthesis. Chem Rev. 2005 Feb;105(2):621-32.

 Chemical & Physical Properties

Density 1.35g/cm3
Boiling Point 862.1ºC at 760mmHg
Melting Point >215°C (dec.)
Molecular Formula C37H46NNaO12
Molecular Weight 719.750
Flash Point 475.2ºC
Exact Mass 719.291748
PSA 204.14000
LogP 5.18780
Storage condition -20°C Freezer
Water Solubility ethanol: soluble50mg/mL | Soluble in water, alcohol and dimethyl sulfoxide.

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS KD1922500
HS Code 2941903000

 Customs

HS Code 2941903000

 Articles30

More Articles
Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition.

Nat. Prod. Rep. 31(4) , 504-13, (2014)

Despite the longstanding importance of polyketide natural products in human medicine, nearly all commercial polyketide-based drugs are prepared through fermentation or semi-synthesis. The paucity of m...

No impact of rifamycin selection on tuberculosis treatment outcome in HIV coinfected patients.

AIDS 27(3) , 481-4, (2013)

Rifabutin has been substituted for rifampicin when treating tuberculosis (TB)/HIV coinfection. However, despite reports of anti-TB treatment failure and acquired rifamycin resistance, long-term clinic...

Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro.

J. Enzyme Inhib. Med. Chem. 25(5) , 715-9, (2010)

Serum paraoxonase (aryldialkylphosphatase, EC 3.1.8.1., PON1) is an esterase protein synthesised by the liver and released into the serum, where it is associated with HDL lipoproteins. In this study, ...

 Synonyms

Rifamycin SV sodium salt
EINECS 238-965-7
Rifamycin SV Monosodium
MFCD00056847
Rifampicin SV sodium
Rifamycin SV hexahydrate sodium salt
Rifamycin sodium
2,7-(Epoxy[1,11,13]pentadecatrienoimino)naphtho[2,1-b]furan-1,11(2H)-dione, 21-(acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, sodium salt, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)- (1:1)
RIFAMYCIN SV SODIUM SALT HEXAHYDRATE
RifaMycin SV MonosodiuM salt
RIFAMYCIN SV-SODIUM
monosodium rifamycin SV
RIFAMYCIN,MONOSODIUMSALT
5,6,9,17,19,21-Hexahydroxy-23-Methoxy-2,4,12,16,18,20,22-heptaMethyl
Sodium (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-acetoxy-2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1.0]triacon ta-1(28),2,4,9,19,21,25(29),26-octaen-27-olate
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