MS049
Modify Date: 2024-02-04 11:20:55
MS049 structure
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Common Name | MS049 | ||
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| CAS Number | 1502816-23-0 | Molecular Weight | 248.364 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 352.6±37.0 °C at 760 mmHg | |
| Molecular Formula | C15H24N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 167.0±26.5 °C | |
Use of MS049MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM respectively.target: PRMT4, PRMT6;IC 50: 34 nM (PRMT4 ), 43 nM (PRMT6 );In vitro: MS 049 reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner. MS 049 treatment (72 h exposure) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC50 = 1.4 ± 0.1 μM (n = 3)) in HEK293 cells. |
| Name | MS049 |
|---|---|
| Synonym | More Synonyms |
| Description | MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM respectively.target: PRMT4, PRMT6;IC 50: 34 nM (PRMT4 ), 43 nM (PRMT6 );In vitro: MS 049 reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner. MS 049 treatment (72 h exposure) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC50 = 1.4 ± 0.1 μM (n = 3)) in HEK293 cells. |
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| Related Catalog | |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 352.6±37.0 °C at 760 mmHg |
| Molecular Formula | C15H24N2O |
| Molecular Weight | 248.364 |
| Flash Point | 167.0±26.5 °C |
| Exact Mass | 248.188858 |
| LogP | 2.21 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.543 |
| Storage condition | -20℃ |
| 1-Piperidineethanamine, N-methyl-4-(phenylmethoxy)- |
| 2-[4-(Benzyloxy)-1-piperidinyl]-N-methylethanamine |
| MS049 hydrochloride |