SR 49059
SR 49059 structure
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Common Name | SR 49059 | ||
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| CAS Number | 150375-75-0 | Molecular Weight | 620.50 | |
| Density | 1.499g/cm3 | Boiling Point | 868ºC at 760mmHg | |
| Molecular Formula | C28H27Cl2N3O7S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 478.8ºC | |
Use of SR 49059SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a Ki vaule of 1.4 nM[1]. |
| Name | SR 49059,(2S)-1-[[(2R,3S)-5-Chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-2-pyrrolidinecarboxamide |
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| Synonym | More Synonyms |
| Description | SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a Ki vaule of 1.4 nM[1]. |
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| Related Catalog | |
| Target |
Ki: 1.4±0.3 nM (vasopressin V1a)[1]. |
| In Vivo | SR 49059 (SR-49059) (2 mg/kg and 30 mg/kg; i.p.; once) shows neuroprotective effects in ischemic brain injury when injected early after occlusion of the middle cerebral artery (MCA)[2]. Animal Model: Male Wistar rats, weighing 300 to 350 g, cerebral focal ischemia model[2] Dosage: 2 mg/kg and 30 mg/kg dissolved in 10% dimethyl sulfoxide Administration: Intraperitoneal injection, once Result: Significantly reduced infarction volume measured at 48 hours after the arterial occlusion. Reduced neurological deficits and ischemic brain edema. |
| References |
| Density | 1.499g/cm3 |
|---|---|
| Boiling Point | 868ºC at 760mmHg |
| Molecular Formula | C28H27Cl2N3O7S |
| Molecular Weight | 620.50 |
| Flash Point | 478.8ºC |
| Exact Mass | 619.09500 |
| PSA | 147.85000 |
| LogP | 5.08430 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.664 |
| InChIKey | CEBYCSRFKCEUSW-NAYZPBBASA-N |
| SMILES | COc1ccc(S(=O)(=O)N2c3ccc(Cl)cc3C(O)(c3ccccc3Cl)C2C(=O)N2CCCC2C(N)=O)cc1OC |
| Storage condition | 2-8°C |
| RIDADR | NONH for all modes of transport |
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The secretion patterns and roles of cardiac and circulating arginine vasopressin during the development of heart failure.
Neuropeptides 51 , 63-73, (2015) The aim of this study is to investigate local cardiac and circulating AVP secretion during heart failure and to determine whether AVP mediates ventricular remodeling.We assessed cardiac function and A... |
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Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats.
Diabetologia 58(5) , 1081-90, (2015) High plasma copeptin, a marker of vasopressin (VP) secretion, has been shown to be associated with the metabolic syndrome and development of type 2 diabetes in humans. The present study was designed t... |
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Vasopressin-2 receptor antagonist attenuates the ability of the lungs to clear edema in an experimental model.
Am. J. Respir. Cell. Mol. Biol. 47(5) , 583-8, (2012) In the last two decades, the role of the alveolar active sodium transport was extensively studied and was found to play a crucial role in regulating alveolar fluid clearance (AFC), and thus in keeping... |
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Name: This assay (PMID: 37558952) monitors the impact of a chemical compound on general aut...
Source: ChEMBL
Target: TERT-RPE1
External Id: CHEMBL5724699
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Name: This assay (PMID: 37558952) monitors the impact of a chemical compound on general aut...
Source: ChEMBL
Target: U2OS
External Id: CHEMBL5724701
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Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802
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Name: This assay (PMID: 37558952) monitors the impact of a chemical compound on ER-phagy fl...
Source: ChEMBL
Target: U2OS
External Id: CHEMBL5724700
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Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
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Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Thermal Shift Assay. Domain: start/stop: M1-S360
Source: ChEMBL
Target: Mitogen-activated protein kinase 1
External Id: CHEMBL5066616
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Name: Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hr...
Source: ChEMBL
Target: Vasopressin V1a receptor
External Id: CHEMBL4276648
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Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5065589
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| reclovaptan |
| cis-Ned 19 |
| INDOL-2-YLCARBONYL)-L-PROLINAMIDE |
| Relcovaptan |
| SR 49059 |